Inhibition of B-cell lymphoma 2 family proteins alters optical redox ratio, mitochondrial polarization, and cell energetics independent of cell state
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomedical Optics"
DOI: 10.1117/1.jbo.27.5.056505
Abstract: Abstract. Significance: The optical redox ratio (ORR) [autofluorescence intensity of the reduced form of nicotinamide adenine dinucleotide (phosphate) (NAD(P)H)/flavin adenine dinucleotide (FAD)] provides a label-free method to quantify cellular metabolism. However, it is unclear whether… read more here.
Keywords: cell; state; inhibition; family ... See more keywords
Polarized mitochondria as guardians of NK cell fitness.
Sign Up to like & getrecommendations! Published in 2021 at "Blood advances"
DOI: 10.1182/bloodadvances.2020003458
Abstract: Distinct metabolic demands accompany lymphocyte differentiation into short-lived effector and long-lived memory cells. How bioenergetics processes are structured in innate natural killer (NK) cells remains unclear. We demonstrate that circulating human CD56Dim (NKDim) cells have… read more here.
Keywords: polarized mitochondria; cell fitness; mitochondrial polarization; guardians cell ... See more keywords