More than just a ticket canceller: the mitochondrial processing peptidase tailors complex precursor proteins at internal cleavage sites
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e20-08-0524
Abstract: Most mitochondrial proteins are synthesized as precursors that carry N-terminal presequences. After they are imported into mitochondria, these targeting signals are cleaved off by the mitochondrial processing peptidase (MPP). Using the mitochondrial tandem protein Arg5,6… read more here.
Keywords: processing peptidase; precursor; mitochondrial processing; cleavage sites ... See more keywords
Mitochondrial Processing Peptidases—Structure, Function and the Role in Human Diseases
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031297
Abstract: Mitochondrial proteins are encoded by both nuclear and mitochondrial DNA. While some of the essential subunits of the oxidative phosphorylation (OXPHOS) complexes responsible for cellular ATP production are synthesized directly in the mitochondria, most mitochondrial… read more here.
Keywords: mitochondrial processing; processing; structure function; processing peptidases ... See more keywords