Mitochondrial protein import machinery conveys stress signals to the cytosol and beyond
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DOI: 10.1002/bies.202200160
Abstract: Mitochondria hold diverse and pivotal roles in fundamental processes that govern cell survival, differentiation, and death, in addition to organismal growth, maintenance, and aging. The mitochondrial protein import system is a major contributor to mitochondrial… read more here.
Keywords: machinery conveys; protein import; mitochondrial protein; import machinery ... See more keywords
Photocontrollable Probes for Mitochondrial Protein Profiling
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DOI: 10.1002/cbic.202200066
Abstract: The mitochondrion is the core site of cell signaling, energy metabolism and biosynthesis. Here, taking advantage of activity‐based probes, we synthesized two photocontrollable probes (YGH‐1 and YGH‐2), composed of a mitochondrial localization moiety “triphenylphosphonium”, a… read more here.
Keywords: probes mitochondrial; mitochondrial protein; protein profiling; photocontrollable probes ... See more keywords
The role of the proteasome in mitochondrial protein quality control.
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DOI: 10.1002/iub.2734
Abstract: The abundance of each cellular protein is dynamically adjusted to the prevailing metabolic and stress conditions by modulation of their synthesis and degradation rates. The proteasome represents the major machinery for the degradation of proteins… read more here.
Keywords: protein quality; quality control; role; mitochondrial protein ... See more keywords
Assessment of Mitochondrial Protein Composition and Purity by Mass Spectroscopy.
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DOI: 10.1007/978-1-0716-1653-6_11
Abstract: While the routine mitochondrial extraction and isolation protocols have not fundamentally changed since the introduction of density gradients, the approaches we use to examine the proteome have. The initial characterisation of mitochondrial proteomes was carried… read more here.
Keywords: mitochondrial protein; protein composition; mass; composition purity ... See more keywords
Poldip2 is an Oxygen-sensitive Mitochondrial Protein that Controls Oxidative/glycolytic Metabolism Balance and Proteasome Activity
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.271
Abstract: The polymerase delta interacting protein 2 (Poldip2) is a nuclear-encoded mitochondrial protein of unknown function. We recently reported that Poldip2 is repressed under hypoxia and that its deficiency results in repressed mitochondrial function and increased… read more here.
Keywords: protein; mitochondrial protein; oxygen sensitive; poldip2 oxygen ... See more keywords
Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28272-1
Abstract: Sustained mitochondrial fitness relies on coordinated biogenesis and clearance. Both processes are regulated by constant targeting of proteins into the organelle. Thus, mitochondrial protein import sets the pace for mitochondrial abundance and function. However, our… read more here.
Keywords: mitochondrial protein; novo serine; serine biosynthesis; protein import ... See more keywords
Mitochondrial diseases caused by dysfunctional mitochondrial protein import.
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DOI: 10.1042/bst20180239
Abstract: Mitochondria are essential organelles which perform complex and varied functions within eukaryotic cells. Maintenance of mitochondrial health and functionality is thus a key cellular priority and relies on the organelle's extensive proteome. The mitochondrial proteome… read more here.
Keywords: mitochondrial protein; protein import; mitochondrial diseases; diseases caused ... See more keywords
The roles of a mitochondrial protein Miga in autophagy.
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DOI: 10.1080/15548627.2022.2153569
Abstract: Miga is an evolutionarily conserved protein that localizes to the outer membrane of mitochondria and mediates endoplasmic reticulum (ER)-mitochondrial contacts through interaction with VAP proteins in the ER. We recently reported that Miga is required… read more here.
Keywords: roles mitochondrial; miga; protein miga; autophagy roles ... See more keywords
MitoCPR: a novel protective mechanism in response to mitochondrial protein import stress
Sign Up to like & getrecommendations! Published in 2018 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.1093/abbs/gmy098
Abstract: Mitochondria are dynamic, double-membrane-bound organelle of eukaryotic cells that have evolved to function in a wide range of cellular processes. They are responsible for oxidative phosphorylation (OXPHOS), producing energy and metabolites, regulating apoptosis and maintaining… read more here.
Keywords: protein; mitochondrial protein; protein import; mitochondrial import ... See more keywords
Palmitic acid induces ceramide accumulation, mitochondrial protein hyperacetylation, and mitochondrial dysfunction in porcine oocytes†
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DOI: 10.1093/biolre/ioy023
Abstract: Abstract Low oocyte quality is a possible causal factor of obesity-induced infertility. High palmitic acid (PA) concentration in follicular fluid is a crucial feature noted in obese women. This study examined how high PA concentration… read more here.
Keywords: mitochondrial protein; dysfunction; palmitic acid; mitochondrial dysfunction ... See more keywords
The metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import
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DOI: 10.1101/2022.04.26.489513
Abstract: Yeast cells employ the cytosolic ubiquitin system to increase the capacity of the mitochondrial import machinery during phases of metabolic transitions. Mitochondria play a key role in cellular energy metabolism. Transitions between glycolytic and respiratory… read more here.
Keywords: conjugase ubc8; protein import; ubiquitin conjugase; mitochondrial protein ... See more keywords