A photo-oxidation driven proximity labeling strategy enables profiling of mitochondrial proteome dynamics in living cells
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc04087e
Abstract: Mapping the proteomic landscape of mitochondria with spatiotemporal precision plays a pivotal role in elucidating the delicate biological functions and complex relationship with other organelles in a variety of dynamic physiological processes which necessitates efficient… read more here.
Keywords: mitochondrial proteome; oxidation; proximity labeling; oxidation driven ... See more keywords
MitoMiner v4.0: an updated database of mitochondrial localization evidence, phenotypes and diseases
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky1072
Abstract: Abstract Increasing numbers of diseases are associated with mitochondrial dysfunction. This is unsurprising given mitochondria have major roles in bioenergy generation, signalling, detoxification, apoptosis and biosynthesis. However, fundamental questions of mitochondrial biology remain, including: which… read more here.
Keywords: evidence; phenotypes diseases; localization evidence; localization ... See more keywords
FMRP attenuates activity dependent modifications in the mitochondrial proteome
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Brain"
DOI: 10.1186/s13041-021-00783-w
Abstract: Homeostatic plasticity is necessary for the construction and maintenance of functional neuronal networks, but principal molecular mechanisms required for or modified by homeostatic plasticity are not well understood. We recently reported that homeostatic plasticity induced… read more here.
Keywords: homeostatic plasticity; activity; activity deprivation; mitochondrial proteome ... See more keywords
Mitochondrial Proteome of Affected Glutamatergic Neurons in a Mouse Model of Leigh Syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.00660
Abstract: Defects in mitochondrial function lead to severe neuromuscular orphan pathologies known as mitochondrial disease. Among them, Leigh Syndrome is the most common pediatric presentation, characterized by symmetrical brain lesions, hypotonia, motor and respiratory deficits, and… read more here.
Keywords: leigh syndrome; model leigh; neurons mouse; model ... See more keywords
Dynamic Mitochondrial Proteome Under Polyamines Treatment in Cardiac Aging
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.840389
Abstract: Age-related alteration of mitochondria causes impaired cardiac function, along with cellular and molecular changes. Polyamines can extend the life span in mice. However, whether polyamines can affect the dynamic mitochondrial proteome, thereby preventing age-related changes… read more here.
Keywords: mitochondrial proteome; dynamic mitochondrial; polyamines treatment; cardiac aging ... See more keywords
Loss of Drosophila Clueless differentially affects the mitochondrial proteome compared to loss of Sod2 and Pink1
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.1004099
Abstract: Mitochondria contain their own DNA, mitochondrial DNA, which encodes thirteen proteins. However, mitochondria require thousands of proteins encoded in the nucleus to carry out their many functions. Identifying the definitive mitochondrial proteome has been challenging… read more here.
Keywords: mitochondrial proteome; loss; drosophila; sod2 pink1 ... See more keywords