Modulating mitochondrial pyruvate carrier: A promising therapeutic target in Parkinson's disease
Sign Up to like & getrecommendations! Published in 2017 at "Movement Disorders"
DOI: 10.1002/mds.26962
Abstract: Mitochondrial pyruvate carrier (MPC) is a key protein complex in the control of cellular metabolism. Recent evidence suggests that a group of antidiabetic compounds, called thiazolidinedione (TZD) insulin sensitizers, slow the entry of pyruvate into… read more here.
Keywords: msdc 0160; pyruvate; target; pyruvate carrier ... See more keywords
Mitochondrial pyruvate carrier as a key regulator of fever and neuroinflammation
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.11.031
Abstract: The mitochondrial pyruvate carrier (MPC) is an inner-membrane transporter that facilitates pyruvate uptake from the cytoplasm into mitochondria. We previously reported that MPC1 protein levels increase in the hypothalamus of animals during fever induced by… read more here.
Keywords: pyruvate; fever; neuroinflammation; pyruvate carrier ... See more keywords
Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.11.002
Abstract: Although metabolic adaptations have been demonstrated to be essential for tumor cell proliferation, the metabolic underpinnings of tumor initiation are poorly understood. We found that the earliest stages of colorectal cancer (CRC) initiation are marked… read more here.
Keywords: initiation; tumor initiation; pyruvate carrier; mitochondrial pyruvate ... See more keywords
The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function.
Sign Up to like & getrecommendations! Published in 2022 at "Cell metabolism"
DOI: 10.1016/j.cmet.2022.03.013
Abstract: Glycolysis, including both lactate fermentation and pyruvate oxidation, orchestrates CD8+ T cell differentiation. However, how mitochondrial pyruvate metabolism and uptake controlled by the mitochondrial pyruvate carrier (MPC) impact T cell function and fate remains elusive. We found… read more here.
Keywords: cell differentiation; pyruvate; memory; mitochondrial pyruvate ... See more keywords
Treating Hepatic Steatosis and Fibrosis by Modulating Mitochondrial Pyruvate Metabolism
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2018.09.017
Abstract: A hepatic comorbidity of metabolic syndrome, known as nonalcoholic fatty liver disease (NAFLD), is increasing in prevalence in conjunction with the pandemics of obesity and diabetes. The spectrum of NAFLD ranges from simple hepatic fat… read more here.
Keywords: fibrosis; metabolism; disease; treating hepatic ... See more keywords
MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cell"
DOI: 10.1016/j.molcel.2022.02.003
Abstract: The mitochondrial pyruvate dehydrogenase complex (PDC) translocates into the nucleus, facilitating histone acetylation by producing acetyl-CoA. We describe a noncanonical pathway for nuclear PDC (nPDC) import that does not involve nuclear pore complexes (NPCs). Mitochondria cluster… read more here.
Keywords: mitochondria nucleus; dehydrogenase complex; pyruvate dehydrogenase; mitochondrial pyruvate ... See more keywords
Enhanced mitochondrial pyruvate transport elicits a robust ROS production to sensitize the antitumor efficacy of interferon-γ in colon cancer
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2018.10.024
Abstract: Metabolic reprogramming is a feature of cancer cells and crucial for tumor growth and metastasis. Interferon-γ (IFNγ) is a cytokine that plays a pivotal role in host antitumor immunity. However, little is known about the… read more here.
Keywords: colon cancer; cancer cells; cancer; antitumor ... See more keywords
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c02093
Abstract: A new series of analogues or derivatives of the previously reported PPARα/γ dual agonist LT175 allowed the identification of ligand 10, which was able to potently activate both PPARα and -γ subtypes as full and… read more here.
Keywords: pyruvate carrier; inhibition; mitochondrial pyruvate; new antidiabetic ... See more keywords
Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000279
Abstract: BACKGROUND AND AIMS NAFLD has become a major metabolic disease worldwide. A few studies have reported the potential relationship between mitochondrial pyruvate carrier (MPC1) and inflammation, fibrosis, and insulin sensitivity in obese or NASH mouse… read more here.
Keywords: acid synthase; pyruvate carrier; lactylation; mitochondrial pyruvate ... See more keywords
Inactivation of mitochondrial pyruvate carrier promotes NLRP3 inflammasome activation and gout development via metabolic reprogramming.
Sign Up to like & getrecommendations! Published in 2023 at "Immunology"
DOI: 10.1111/imm.13628
Abstract: The NLRP3 inflammasome plays a crucial role in innate immunity and is involved in the pathogenesis of autoinflammatory diseases. Glycolysis regulates NLRP3 inflammasome activation in macrophages. However, how lactic acid fermentation and pyruvate oxidation controlled… read more here.
Keywords: gout; inflammasome activation; mitochondrial pyruvate; nlrp3 inflammasome ... See more keywords
The Mitochondrial Pyruvate Carrier Coupling Glycolysis and the Tricarboxylic Acid Cycle Is Required for the Asexual Reproduction of Toxoplasma gondii
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.05043-22
Abstract: T. gondii is a zoonotic parasite capable of infecting many warm-blooded organisms, including humans. Among others, a feature that allows it to parasitize multiple hosts is its exceptional metabolic plasticity. ABSTRACT Toxoplasma gondii is an… read more here.
Keywords: mitochondrion; growth; mitochondrial pyruvate; gondii ... See more keywords