Evidence for the Role of BAG3 in Mitochondrial Quality Control in Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25476
Abstract: Mitochondrial abnormalities impact the development of myofibrillar myopathies. Therefore, understanding the mechanisms underlying the removal of dysfunctional mitochondria from cells is of great importance toward understanding the molecular events involved in the genesis of cardiomyopathy.… read more here.
Keywords: bag3; bag3 mitochondrial; mitochondrial quality; role bag3 ... See more keywords
Notch1 provides myocardial protection by improving mitochondrial quality control
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27892
Abstract: Mitochondrial quality control is a new target for myocardial protection. Notch signaling plays an important role in heart development, maturation, and repair. However, the role of Notch in the myocardial mitochondrial quality control remains elusive.… read more here.
Keywords: quality control; myocardial protection; mitochondrial quality;
Mitochondrial quality control proteases and their modulation for cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Medicinal Research Reviews"
DOI: 10.1002/med.21929
Abstract: Mitochondria, the main provider of energy in eukaryotic cells, contains more than 1000 different proteins and is closely related to the development of cells. However, damaged proteins impair mitochondrial function, further contributing to several human… read more here.
Keywords: mitochondrial quality; quality control; control; cancer ... See more keywords
Molecular mechanisms of coronary microvascular endothelial dysfunction in diabetes mellitus: focus on mitochondrial quality surveillance.
Sign Up to like & getrecommendations! Published in 2022 at "Angiogenesis"
DOI: 10.1007/s10456-022-09835-8
Abstract: Coronary microvascular endothelial dysfunction is both a culprit and a victim of diabetes, and can accelerate diabetes-related microvascular and macrovascular complications by promoting vasoconstrictive, pro-inflammatory and pro-thrombotic responses. Perturbed mitochondrial function induces oxidative stress, disrupts… read more here.
Keywords: coronary microvascular; mitochondrial quality; microvascular endothelial; endothelial dysfunction ... See more keywords
Mitochondrial Quality Control and Disease: Insights into Ischemia-Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0503-9
Abstract: Mitochondria are key regulators of cell fate during disease. They control cell survival via the production of ATP that fuels cellular processes and, conversely, cell death via the induction of apoptosis through release of pro-apoptotic… read more here.
Keywords: control; disease; mitochondrial quality; control mechanisms ... See more keywords
Mitochondrial Quality Control in Cartilage Damage and Osteoarthritis: New Insights and Potential Therapeutic Targets.
Sign Up to like & getrecommendations! Published in 2021 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2021.10.009
Abstract: Osteoarthritis (OA) is a multifactorial arthritic disease of weight-bearing joints concomitant with chronic and intolerable pain, loss of locomotion and impaired quality of life in the elderly population. Although the prevalence of OA increases with… read more here.
Keywords: quality control; cartilage damage; mitochondrial quality; damage ... See more keywords
Mitochondrial quality control in pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101426
Abstract: Mechanisms underlying the pathogenesis of pulmonary fibrosis remain incompletely understood. Emerging evidence suggests changes in mitochondrial quality control are a critical determinant in many lung diseases, including chronic obstructive pulmonary disease, asthma, pulmonary hypertension, acute… read more here.
Keywords: quality control; pulmonary fibrosis; mitochondrial quality;
Peroxiredoxin 3 deficiency induces cardiac hypertrophy and dysfunction by impaired mitochondrial quality control
Sign Up to like & getrecommendations! Published in 2022 at "Redox Biology"
DOI: 10.1016/j.redox.2022.102275
Abstract: Mitochondrial quality control (MQC) consists of multiple processes: the prevention of mitochondrial oxidative damage, the elimination of damaged mitochondria via mitophagy and mitochondrial fusion and fission. Several studies proved that MQC impairment causes a plethora… read more here.
Keywords: dysfunction; prdx3; quality control; mitochondrial quality ... See more keywords
Genipin protects the liver from ischemia/reperfusion injury by modulating mitochondrial quality control
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.05.002
Abstract: ABSTRACT Hepatic ischemia and reperfusion (IR) injury is closely linked to oxidative mitochondrial damage. Since mitochondrial quality control (QC) plays a pivotal role in the recovery of impaired mitochondrial function, mitochondrial QC has emerged as… read more here.
Keywords: genipin; mitochondrial quality; ischemia reperfusion; reperfusion injury ... See more keywords
Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure
Sign Up to like & getrecommendations! Published in 2017 at "Autophagy"
DOI: 10.1080/15548627.2017.1325062
Abstract: ABSTRACT We previously reported that facilitating the clearance of damaged mitochondria through macroautophagy/autophagy protects against acute myocardial infarction. Here we characterize the impact of exercise, a safe strategy against cardiovascular disease, on cardiac autophagy and… read more here.
Keywords: autophagic flux; exercise; mitochondrial quality; heart failure ... See more keywords
Alternative mitochondrial quality control mediated by extracellular release
Sign Up to like & getrecommendations! Published in 2020 at "Autophagy"
DOI: 10.1080/15548627.2020.1848130
Abstract: ABSTRACT Mitochondrial quality control, which is crucial for maintaining cellular homeostasis, has been considered to be achieved exclusively through mitophagy. Here we report an alternative mitochondrial quality control pathway mediated by extracellular mitochondria release. By… read more here.
Keywords: protein; control; extracellular mitochondria; mitochondrial quality ... See more keywords