UBXD1 is a mitochondrial recruitment factor for p97/VCP and promotes mitophagy
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30963-z
Abstract: Clearance of damaged mitochondria through mitophagy is critical for maintaining mitochondrial fidelity and the prevention of neurodegeneration. Here, we report on the UBX domain-containing, p97/VCP cofactor UBXD1/UBXN6/UBXDC2 and its role in mitophagy. Recognizing depolarized mitochondria… read more here.
Keywords: mitophagy ubxd1; mitochondrial recruitment; p97 vcp; p97 ... See more keywords
WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2052461
Abstract: ABSTRACT The mammalian Atg18 ortholog WIPI2 is a key regulator of LC3 lipidation to promote autophagosome biogenesis during nonselective macroautophagy, while its functions in selective autophagy such as mitophagy remain largely unexplored. In this study,… read more here.
Keywords: recruitment vcp; wipi2; damaged mitochondria; vcp ... See more keywords