Metabolism of hyperpolarized 13C‐acetoacetate to β‐hydroxybutyrate detects real‐time mitochondrial redox state and dysfunction in heart tissue
Sign Up to like & getrecommendations! Published in 2019 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4091
Abstract: Mitochondrial dysfunction is considered to be an important component of many metabolic diseases yet there is no reliable imaging biomarker for monitoring mitochondrial damage in vivo. A large prior literature on inter‐conversion of β‐hydroxybutyrate and… read more here.
Keywords: mitochondrial redox; redox state; acetoacetate; hydroxybutyrate ... See more keywords
Live cell imaging of mitochondrial redox state in mammalian cells and yeast.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2019.11.008
Abstract: The redox state of mitochondria is determined by the levels of reducing and oxidizing species in the organelle, which reflects mitochondrial metabolic activity and overall fitness. Mitochondria are also the primary endogenous source of reactive… read more here.
Keywords: cells yeast; redox state; mitochondrial redox; mammalian cells ... See more keywords
A new insight on elderberry anthocyanins bioactivity: Modulation of mitochondrial redox chain functionality and cell redox state
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.03.019
Abstract: Abstract An elderberry anthocyanin-enriched extract was prepared and characterized in terms of phenolic composition and bioactivity, in order to evaluate its potential to target oxidative stress and mitochondrial dysfunction, which are early pathological events detected… read more here.
Keywords: redox; mitochondrial redox; redox state; enriched extract ... See more keywords
Mitochondria-Targeted Mesoporous Organic Silica Nanoplatforms for Overcoming Cisplatin Resistance by Disturbing Mitochondrial Redox Homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.875818
Abstract: Cisplatin (also known as DDP) resistance is one of the biggest challenges in the treatment of ovarian cancer. Recent studies have found that mitochondrion, as a potential target of DDP, participates in drug-related apoptosis and… read more here.
Keywords: mitochondrial redox; organic silica; ddp; resistance ... See more keywords
How the Disruption of Mitochondrial Redox Signalling Contributes to Ageing
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DOI: 10.3390/antiox12040831
Abstract: In the past, mitochondrial reactive oxygen species (mtROS) were considered a byproduct of cellular metabolism. Due to the capacity of mtROS to cause oxidative damage, they were proposed as the main drivers of ageing and… read more here.
Keywords: mitochondrial redox; disruption mitochondrial; contributes ageing; redox signalling ... See more keywords
Inhibition of Mitochondrial Redox Signaling with MitoQ Prevents Metastasis of Human Pancreatic Cancer in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14194918
Abstract: Simple Summary If improvements of diagnostic techniques and methodologies allow to increasingly detect cancers at the premetastatic stage, metastases still account for about 90% of cancer patient deaths in the clinics. Indeed, there is currently… read more here.
Keywords: mitochondrial redox; cell; pancreatic cancer; cancer ... See more keywords