Tetrahydrocurcumin ameliorates homocysteine‐mediated mitochondrial remodeling in brain endothelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26145
Abstract: Homocysteine (Hcy) causes endothelial dysfunction by inducing oxidative stress in most neurodegenerative disorders. This dysfunction is highly correlated with mitochondrial dynamics such as fusion and fission. However, there are no strategies to prevent Hcy‐induced mitochondrial… read more here.
Keywords: hcy; microscopy; brain endothelial; thc ... See more keywords
POLG mutations lead to abnormal mitochondrial remodeling during neural differentiation of human pluripotent stem cells via SIRT3/AMPK pathway inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2022.2044136
Abstract: ABSTRACT We showed previously that POLG mutations cause major changes in mitochondrial function, including loss of mitochondrial respiratory chain (MRC) complex I, mitochondrial DNA (mtDNA) depletion and an abnormal NAD+/NADH ratio in both neural stem… read more here.
Keywords: polg mutations; mitochondrial remodeling; differentiation; stem ... See more keywords
Exercise and mitochondrial remodeling to prevent age-related neurodegeneration
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Physiology"
DOI: 10.1152/japplphysiol.00611.2022
Abstract: Healthy brain activity requires precise ion and energy management creating a strong reliance on mitochondrial function. Age-related neurodegeneration leads to a decline in mitochondrial function and increased oxidative stress, with associated declines in mitochondrial mass,… read more here.
Keywords: age related; mitochondrial remodeling; brain; related neurodegeneration ... See more keywords
The acute removal of metformin induces mitochondrial remodeling and increases mitochondrial respiration
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732402
Abstract: Metformin is a candidate to slow biological aging and extend healthspan, as it reduces the risk of morbidity and mortality in people with type 2 diabetes. However, it is not clear how metformin impacts individuals… read more here.
Keywords: mitochondrial remodeling; hcr; met day; physiology ... See more keywords
Molecular Regulators of Muscle Mass and Mitochondrial Remodeling Are Not Influenced by Testosterone Administration in Young Women
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.874748
Abstract: Testosterone (T) administration has previously been shown to improve muscle size and oxidative capacity. However, the molecular mechanisms underlying these adaptations in human skeletal muscle remain to be determined. Here, we examined the effect of… read more here.
Keywords: administration; mitochondrial remodeling; regulators muscle; molecular regulators ... See more keywords
Exercise-Boosted Mitochondrial Remodeling in Parkinson’s Disease
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DOI: 10.3390/biomedicines10123228
Abstract: Parkinson’s disease (PD) is a movement disorder characterized by the progressive degeneration of dopaminergic neurons resulting in dopamine deficiency in the striatum. Given the estimated escalation in the number of people with PD in the… read more here.
Keywords: disease; mitochondrial remodeling; parkinson disease; boosted mitochondrial ... See more keywords
IGF-1 Signaling Regulates Mitochondrial Remodeling during Myogenic Differentiation
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DOI: 10.3390/nu14061249
Abstract: Skeletal muscle is essential for locomotion, metabolism, and protein homeostasis in the body. Mitochondria have been considered as a key target to regulate metabolic switch during myo-genesis. The insulin-like growth factor 1 (IGF-1) signaling through… read more here.
Keywords: igf signaling; mitochondrial remodeling; remodeling myogenic; igf ... See more keywords