Mitochondrial replacement by genome transfer in human oocytes: Efficacy, concerns, and legality
Sign Up to like & getrecommendations! Published in 2021 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12356
Abstract: Pathogenic mitochondrial (mt)DNA mutations, which often cause life‐threatening disorders, are maternally inherited via the cytoplasm of oocytes. Mitochondrial replacement therapy (MRT) is expected to prevent second‐generation transmission of mtDNA mutations. However, MRT may affect the… read more here.
Keywords: replacement; mitochondrial replacement; human oocytes; replacement genome ... See more keywords
Mitochondrial Replacement Techniques
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bioethical Inquiry"
DOI: 10.1007/s11673-018-9873-6
Abstract: In this article, I draw on research carried out in Europe, primarily in Germany, on patients’ and scientists’ perspectives on mitochondrial replacement techniques (MRTs) in order to explore some of the complexities related to collective… read more here.
Keywords: patient; governance; replacement techniques; mitochondrial replacement ... See more keywords
Development of mitochondrial replacement therapy: A review
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DOI: 10.1016/j.heliyon.2020.e04643
Abstract: Mitochondrial replacement therapy (MRT) is a new form of reproductive invitro fertilization (IVF) which works on the principle of replacing a women's abnormal mitochondrial DNA (mt-DNA) with the donor's healthy one. MRT include different techniques… read more here.
Keywords: replacement therapy; review; development; mitochondrial replacement ... See more keywords
First birth following spindle transfer for mitochondrial replacement therapy: hope and trepidation.
Sign Up to like & getrecommendations! Published in 2017 at "Reproductive biomedicine online"
DOI: 10.1016/j.rbmo.2017.02.004
Abstract: In this issue, Zhang et al. (2017) report the birth of a healthy boy after mitochondrial replacement therapy (MRT) by spindle transfer to prevent transmission of mitochondrial disease from mother to child. The case was… read more here.
Keywords: replacement therapy; spindle transfer; first birth; mitochondrial replacement ... See more keywords
Mexico and mitochondrial replacement techniques: what a mess
Sign Up to like & getrecommendations! Published in 2018 at "British Medical Bulletin"
DOI: 10.1093/bmb/ldy037
Abstract: Background The first live birth following the use of a new reproductive technique, maternal spindle transfer (MST), which is a mitochondrial replacement technique (MRT), was accomplished by dividing the execution of the MST procedure between… read more here.
Keywords: replacement; new reproductive; mitochondrial replacement; mexico mitochondrial ... See more keywords
Comment on mitochondrial replacement techniques and the birth of the ‘first’
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Law and the Biosciences"
DOI: 10.1093/jlb/lsx021
Abstract: Palacios-Gonzalez and Medina-Arellano present an insightful account of the world’s first birth following the use of mitochondrial replacement techniques (MRT) by a US doctor, Dr Zhang, through his affiliated clinic in Mexico. Their article contributes… read more here.
Keywords: law; mitochondrial replacement; replacement techniques; birth first ... See more keywords
Gendering the seed: Mitochondrial replacement techniques and the erasure of the maternal.
Sign Up to like & getrecommendations! Published in 2021 at "Bioethics"
DOI: 10.1111/bioe.12868
Abstract: In order to avoid the implication that 'mitochondrial replacement techniques' (MRT) would produce 'three parent babies', discourses around these techniques typically dismiss the contribution of the mitochondria to genetic parenthood and personal identity. According to… read more here.
Keywords: seed; dna; mitochondrial replacement; contribution ... See more keywords
Should mitochondrial replacement therapy be funded by the National Health Service?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Ethics"
DOI: 10.1136/medethics-2019-106053
Abstract: A clinical trial on mitochondrial replacement therapy (MRT) is currently being conducted and if this technique proves effective, National Health Service (NHS) England will fund MRT through the highly specialised services (HSS) funding stream. This… read more here.
Keywords: replacement therapy; mitochondrial replacement; health service; mrt ... See more keywords