Cytotoxicity of quercetin is related to mitochondrial respiration impairment in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2022 at "Yeast"
DOI: 10.1002/yea.3818
Abstract: Quercetin is a flavonol ubiquitously present in fruits and vegetables that shows a potential therapeutic use in non‐transmissible chronic diseases, such as cancer and diabetes. Although this phytochemical has shown promising health benefits, the molecular… read more here.
Keywords: respiration impairment; respiration; mitochondrial respiration; cytotoxicity quercetin ... See more keywords
Assessment of the Effects of Drugs on Mitochondrial Respiration.
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DOI: 10.1007/978-1-0716-1270-5_9
Abstract: Mitochondria are targets of newly synthesized drugs and being tested for the treatment of various diseases caused or accompanied by disruption of cellular bioenergetics. In drug development, it is necessary to test for drug-induced changes… read more here.
Keywords: mitochondrial respiration; effects drugs; drugs mitochondrial; assessment effects ... See more keywords
Assaying Mitochondrial Respiration as an Indicator of Cellular Metabolism and Fitness.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6960-9_7
Abstract: Mitochondrial respiration is the most important generator of cellular energy under most circumstances. It is a process of energy conversion of substrates into ATP. The Seahorse equipment allows measuring oxygen consumption rate (OCR) in living… read more here.
Keywords: mitochondrial respiration; indicator cellular; cellular metabolism; respiration ... See more keywords
In vitro effects of antipsychotics on mitochondrial respiration
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01665-8
Abstract: Assessment of drug-induced mitochondrial dysfunctions is important in drug development as well as in the understanding of molecular mechanism of therapeutic or adverse effects of drugs. The aim of this study was to investigate the… read more here.
Keywords: mitochondrial respiration; effects antipsychotics; antipsychotics mitochondrial; vitro effects ... See more keywords
Mitochondrial respiration in C57BL/6 substrains varies in response to myocardial infarction
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-021-09884-6
Abstract: The C57BL/6 mouse strain have been commonly used for the genetic background animal models and experimental research. There are several major sources of C57BL/6 substrains for the biomedical research community which display genetic and phenotypic… read more here.
Keywords: mitochondrial respiration; response; myocardial infarction; respiration ... See more keywords
Active mitochondrial respiration in cancer: a target for the drug.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-021-04281-4
Abstract: The relative contribution of mitochondrial respiration and subsequent energy production in malignant cells has remained controversial to date. Enhanced aerobic glycolysis and impaired mitochondrial respiration have gained more attention in the metabolic study of cancer.… read more here.
Keywords: mitochondrial respiration; respiration cancer; respiration; active mitochondrial ... See more keywords
Succinate receptor 1 inhibits mitochondrial respiration in cancer cells addicted to glutamine.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.11.024
Abstract: Cancer cells display metabolic alterations to meet the bioenergetic demands for their high proliferation rates. Succinate is a central metabolite of the tricarboxylic acid (TCA) cycle, but was also shown to act as an oncometabolite… read more here.
Keywords: mitochondrial respiration; sucnr1; cancer cells; cancer ... See more keywords
Different ketogenesis strategies lead to disparate seizure outcomes
Sign Up to like & getrecommendations! Published in 2018 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2018.04.011
Abstract: BACKGROUND Despite the introduction of new medicines to treat epilepsy over the last 50 years, the number of patients with poorly-controlled seizures remains unchanged. Metabolism-based therapies are an underutilized treatment option for this population. We… read more here.
Keywords: mitochondrial respiration; ketogenesis strategies; different ketogenesis; mice ... See more keywords
An integrative approach to the regulation of mitochondrial respiration during exercise: Focus on high-intensity exercise
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DOI: 10.1016/j.redox.2020.101478
Abstract: During exercise, muscle ATP demand increases with intensity, and at the highest power output, ATP consumption may increase more than 100-fold above the resting level. The rate of mitochondrial ATP production during exercise depends on… read more here.
Keywords: mitochondrial respiration; focus; intensity exercise; high intensity ... See more keywords
Ischemia With Preconditioning in Wistar Rats Maintains Mitochondrial Respiration, Even With Mild Hepatocellular Disturbance.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2018.02.026
Abstract: INTRODUCTION In hepatectomy or liver transplantation, preconditioning is a procedure indicated to protect the organ from ischemia-reperfusion injury (I-R). OBJECTIVE Evaluate the effect of preconditioning after hepatic I-R in Wistar rats, through mitochondrial respiration, liver… read more here.
Keywords: mitochondrial respiration; preconditioning wistar; respiration; ischemia preconditioning ... See more keywords
Hyperglycemia alters mitochondrial respiration efficiency and mitophagy in human podocytes.
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DOI: 10.1016/j.yexcr.2021.112758
Abstract: Podocytes constitute the outer layer of the renal glomerular filtration barrier. Their energy requirements strongly depend on efficient oxidative respiration, which is tightly connected with mitochondrial dynamics. We hypothesized that hyperglycemia modulates energy metabolism in… read more here.
Keywords: mitochondrial respiration; respiration; hyperglycemia alters; hyperglycemia ... See more keywords