Reprogramming of Mitochondrial Respiratory Chain Complex by Targeting SIRT3‐COX4I2 Axis Attenuates Osteoarthritis Progression
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202206144
Abstract: Mitochondrial homeostasis is of great importance for cartilage integrity and associated with the progression of osteoarthritis (OA); however, the underlying mechanisms are unknown. This study aims to investigate the role of mitochondrial deacetylation reaction and… read more here.
Keywords: respiratory chain; sirt3; progression; mitochondrial respiratory ... See more keywords
Docosahexaenoic acid increased MeCP2 mediated mitochondrial respiratory complexes II and III enzyme activities in cortical astrocytes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23002
Abstract: Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the methyl‐CpG‐binding protein 2 (MeCP2) in the neurons and glial cells of the central nervous system. Currently, therapeutics for RTT is aimed at restoring… read more here.
Keywords: iii enzyme; docosahexaenoic acid; expression; dha ... See more keywords
Alternative mitochondrial respiratory chains from two crustaceans: Artemia franciscana nauplii and the white shrimp, Litopenaeus vannamei
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-018-9753-0
Abstract: Mitochondrial ATP is synthesized by coupling between the electron transport chain and complex V. In contrast, physiological uncoupling of these processes allows mitochondria to consume oxygen at high rates without ATP synthesis. Such uncoupling mechanisms… read more here.
Keywords: mitochondrial respiratory; franciscana nauplii; alternative redox; redox enzymes ... See more keywords
The oral administration of D-galactose induces abnormalities within the mitochondrial respiratory chain in the brain of rats
Sign Up to like & getrecommendations! Published in 2017 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-017-9972-9
Abstract: D-Galactose (D-gal) chronic administration via intraperitoneal and subcutaneous routes has been used as a model of aging and Alzheimer disease in rodents. Intraperitoneal and subcutaneous administration of D-gal causes memory impairments, a reduction in the… read more here.
Keywords: mitochondrial respiratory; administration; respiratory chain; respiratory ... See more keywords
Variation in mitochondrial respiratory capacity and myosin heavy chain composition in repeated muscle biopsies.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2018.06.029
Abstract: Skeletal muscle is a heterogeneous tissue and it is essential to know the methodological variation and reliability when measuring aspects of muscle function. We assessed the methodological and biological variation when measuring mitochondrial respiratory capacity… read more here.
Keywords: mitochondrial respiratory; biopsy; variation; muscle biopsies ... See more keywords
Mitochondrial respiratory chain damage and mitochondrial fusion disorder are involved in liver dysfunction of fluoride-induced mice.
Sign Up to like & getrecommendations! Published in 2019 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2019.125099
Abstract: Our previous study showed that excessive fluoride (F) intake can induce liver dysfunction. The aim of this study was to investigate the mechanisms of F-induced mitochondrial damage resulting in liver dysfunction. Damaged mitochondrial ultrastructure and… read more here.
Keywords: mitochondrial respiratory; respiratory chain; dysfunction; liver dysfunction ... See more keywords
Quantitative proteomics reveals mitochondrial respiratory chain as a dominant target for carbon ion radiation: Delayed reactive oxygen species generation caused DNA damage
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.449
Abstract: ABSTRACT Heavy ion radiotherapy has shown great promise for cancer therapy. Understanding the cellular response mechanism to heavy ion radiation is required to explore measures of overcoming devastating side effects. Here, we performed a quantitative… read more here.
Keywords: mitochondrial respiratory; ion radiation; respiratory chain; ion ... See more keywords
Thinned young apple polysaccharide improves hepatic metabolic disorder in high-fat diet-induced obese mice by activating mitochondrial respiratory functions
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2017.03.055
Abstract: Abstract Apple polysaccharides have been previously demonstrated to have beneficial effects on hepatic metabolic functions. Approximately 1.9 million tons of young apples are thinned and abandoned annually in China, and whether the polysaccharide derived from… read more here.
Keywords: mitochondrial respiratory; thinned young; polysaccharide; apple ... See more keywords
Diminished force production and mitochondrial respiratory deficits are strain‐dependent myopathies of subacute limb ischemia
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Vascular Surgery"
DOI: 10.1016/j.jvs.2016.04.041
Abstract: Objective: Reduced skeletal muscle mitochondrial function might be a contributing mechanism to the myopathy and activity based limitations that typically plague patients with peripheral arterial disease (PAD). We hypothesized that mitochondrial dysfunction, myofiber atrophy, and… read more here.
Keywords: respiratory; muscle; mitochondrial respiratory; limb ischemia ... See more keywords
Defective Complex III Mitochondrial Respiratory Chain Due to A Novel Variant in CYC1 Gene Masquerades Acute Demyelinating Syndrome or Leber Hereditary Optic Neuropathy.
Sign Up to like & getrecommendations! Published in 2021 at "Mitochondrion"
DOI: 10.1016/j.mito.2021.07.001
Abstract: Complex III (CIII) is the third out of five mitochondrial respiratory chain complexes residing at the mitochondrial inner membrane. The assembly of 10 subunits encoded by nuclear DNA and one by mitochondrial DNA result in… read more here.
Keywords: mitochondrial respiratory; chain; respiratory chain; complex iii ... See more keywords
IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Immunology"
DOI: 10.1038/cmi.2016.71
Abstract: Obesity and associated metabolic diseases are characterized by a chronic low-grade inflammatory state with the infiltration of many inflammatory cells, especially macrophages. Immune molecules, including some cytokines, have a close relationship with metabolism. Interleukin (IL)-25… read more here.
Keywords: mitochondrial respiratory; obesity; lipolysis; respiratory capacity ... See more keywords