SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1–Nrf2
Sign Up to like & getrecommendations! Published in 2019 at "Nature Immunology"
DOI: 10.1038/s41590-019-0482-2
Abstract: Whether screening the metabolic activity of immune cells facilitates discovery of molecular pathology remains unknown. Here we prospectively screened the extracellular acidification rate as a measure of glycolysis and the oxygen consumption rate as a… read more here.
Keywords: mitochondrial retrograde; keap1 nrf2; retrograde signaling; sdha gain ... See more keywords
Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1007567
Abstract: Mitochondrial dysfunction activates the mitochondrial retrograde signaling pathway, resulting in large scale changes in gene expression. Mitochondrial retrograde signaling in neurons is poorly understood and whether retrograde signaling contributes to cellular dysfunction or is protective… read more here.
Keywords: mitochondrial retrograde; erk ets; retrograde signaling; ras erk ... See more keywords
Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Biochemistry and Nutrition"
DOI: 10.3164/jcbn.18-37
Abstract: Recent investigations have clarified the importance of mitochondria in various age-related degenerative diseases, including late-onset Alzheimer’s disease and Parkinson’s disease. Although mitochondrial disturbances can be involved in every step of disease progression, several observations have… read more here.
Keywords: isr atf4; mitochondrial retrograde; retrograde signaling; atf4 pathway ... See more keywords
Adipose-Derived Mesenchymal Stem Cells Inhibit JNK-Mediated Mitochondrial Retrograde Pathway to Alleviate Acetaminophen-Induced Liver Injury
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12010158
Abstract: Acetaminophen (APAP) is the major cause of drug-induced liver injury, with limited treatment options. APAP overdose invokes excessive oxidative stress that triggers mitochondria-to-nucleus retrograde pathways, contributing to APAP-induced liver injury (AILI). Mesenchymal stem cell therapy… read more here.
Keywords: mitochondrial retrograde; liver injury; mesenchymal stem; induced liver ... See more keywords