Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy
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DOI: 10.1021/acs.jmedchem.2c01092
Abstract: The mitochondrial rhomboid protease PARL regulates mitophagy by balancing intramembrane proteolysis of PINK1 and PGAM5. It has been implicated in the pathogenesis of Parkinson’s disease, but its investigation as a possible therapeutic target is challenging… read more here.
Keywords: ketoamide inhibitors; parl; rhomboid protease; mitochondrial rhomboid ... See more keywords