Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1101/2022.11.05.515295
Abstract: Maintaining mitochondrial function is critical to an improved health span and lifespan. Introducing mild stress by inhibiting mitochondrial translation invokes the mitochondrial unfolded protein response (UPRmt) and increases lifespan in several animal models. Notably, lower… read more here.
Keywords: metabolic health; mitochondrial ribosomal; expression; mice ... See more keywords
Aim23p Interacts with the Yeast Mitochondrial Ribosomal Small Subunit
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry (Moscow)"
DOI: 10.1134/s000629791901005x
Abstract: Protein synthesis in mitochondria is generally organized in a bacterial-like manner but, at the same time, possesses several unique traits. Translation initiation in mitochondria is regulated by two protein factors, mtIF2 and mtIF3. Previously we… read more here.
Keywords: small subunit; yeast mitochondrial; interacts yeast; mitochondrial ribosomal ... See more keywords
Classification of the mitochondrial ribosomal protein-associated molecular subtypes and identified a serological diagnostic biomarker in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Surgery"
DOI: 10.3389/fsurg.2022.1062659
Abstract: Purpose The objective of this study was to sort out innovative molecular subtypes associated with mitochondrial ribosomal proteins (MRPs) to predict clinical therapy response and determine the presence of circulating markers in hepatocellular carcinoma (HCC)… read more here.
Keywords: hepatocellular carcinoma; molecular subtypes; mitochondrial ribosomal; ribosomal protein ... See more keywords
MRPL42 is activated by YY1 to promote lung adenocarcinoma progression
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DOI: 10.7150/jca.52277
Abstract: Mammalian mitochondrial ribosomal proteins are a group of protein factors encoded by nuclear genes, responsible for the synthesis of proteins in mitochondria. As a member of mitochondrial ribosomal proteins, MRPL42 (mitochondrial ribosomal protein L42) belongs… read more here.
Keywords: lung adenocarcinoma; mrpl42 activated; mrpl42; promote ... See more keywords