Quantitative Analysis of Mitochondrial RNA in Living Cells with a Dual-Color Imaging System.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202301132
Abstract: Accurate quantification and dynamic expression profiling of mitochondrial RNA (mtRNA for short) are critical for illustrating their cellular functions. However, there lack methods for precise detection of mtRNA in situ due to the delivery restrictions… read more here.
Keywords: quantitative analysis; color imaging; imaging system; dual color ... See more keywords
The emergent role of mitochondrial RNA modifications in metabolic alterations
Sign Up to like & getrecommendations! Published in 2022 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1753
Abstract: Mitochondrial epitranscriptomics refers to the modifications occurring in all the different RNA types of mitochondria. Although the number of mitochondrial RNA modifications is less than those in cytoplasm, substantial evidence indicates that they play a… read more here.
Keywords: mitochondrial rna; rna modifications; emergent role; metabolic alterations ... See more keywords
Analysis of Mitochondrial RNA-Processing Defects in Patient-Derived Tissues by qRT-PCR and RNAseq.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6824-4_23
Abstract: Transcription of the mitochondrial genome yields three large polycistronic transcripts that undergo multiple endonucleolytic processing steps, before resulting in functional mRNAs, tRNAs, and rRNAs. Cleavage of the large precursor transcripts is mainly performed by the… read more here.
Keywords: pcr rnaseq; processing; rnase; rna processing ... See more keywords
Homozygous n.64C>T mutation in mitochondrial RNA-processing endoribonuclease gene causes Cartilage Hair Hypoplasia Syndrome in two siblings.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medical genetics"
DOI: 10.1016/j.ejmg.2021.104136
Abstract: Cartilage hair hypoplasia syndrome (OMIM # 250250) is a rare autosomal recessive metaphyseal dysplasia, characterized by disproportionate short stature, hair hypoplasia and variable extra-skeletal manifestations, including immunodeficiency, anemia, intestinal diseases and predisposition to cancers. Cartilage… read more here.
Keywords: mutation mitochondrial; cartilage hair; hypoplasia syndrome; rna processing ... See more keywords
Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in parasitology"
DOI: 10.1016/j.pt.2020.01.006
Abstract: Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ribosomal RNAs… read more here.
Keywords: grammar mitochondrial; rna; lexis grammar; rna processing ... See more keywords
Mitochondrial RNA granules are critically dependent on mtDNA replication factors Twinkle and mtSSB
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz047
Abstract: Abstract Newly synthesized mitochondrial RNA is concentrated in structures juxtaposed to nucleoids, called RNA granules, that have been implicated in mitochondrial RNA processing and ribosome biogenesis. Here we show that two classical mtDNA replication factors,… read more here.
Keywords: mtdna replication; replication factors; rna; rna granules ... See more keywords
The mitochondrial RNA granule modulates manganese-dependent cell toxicity
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1101/2022.01.04.474973
Abstract: Prolonged manganese exposure causes manganism, a neurodegenerative movement disorder. The identity of adaptive and non-adaptive cellular processes targeted by manganese remains mostly unexplored. Here we study mechanisms engaged by manganese in genetic cellular models known… read more here.
Keywords: mitochondrial rna; manganese exposure; rna granule; granule ... See more keywords
Resveratrol Attenuates the Mitochondrial RNA-Mediated Cellular Response to Immunogenic Stress
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087403
Abstract: Human mitochondria contain a circular genome that encodes 13 subunits of the oxidative phosphorylation system. In addition to their role as powerhouses of the cells, mitochondria are also involved in innate immunity as the mitochondrial… read more here.
Keywords: response immunogenic; mitochondrial rna; response; immunogenic stress ... See more keywords
Highly efficient 5' capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.42179
Abstract: Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD+ and NADH, using NAD+ and NADH as non-canonical initiating nucleotides for transcription… read more here.
Keywords: nad nadh; rna nad; human mitochondrial; rna ... See more keywords