Markers for Mitochondrial ROS Status.
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DOI: 10.1007/978-1-0716-1653-6_15
Abstract: Mitochondria actively participate in oxygenic metabolism and are one of the major sources of reactive oxygen species (ROS) production in plant cells. However, instead of measuring ROS concentrations in organelles it is more worthwhile to… read more here.
Keywords: mitochondrial ros; production; ros; ros status ... See more keywords
Measurement of Mitochondrial ROS Formation.
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DOI: 10.1007/978-1-4939-7831-1_24
Abstract: Reactive oxygen species (ROS) are involved in both physiological and pathological processes. This widely accepted concept is based more on the effects of antioxidant interventions than on reliable assessments of rates and sites of intracellular… read more here.
Keywords: ros formation; mitochondrial ros; measurement mitochondrial; formation ... See more keywords
Modelling mitochondrial ROS production by the respiratory chain
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03381-1
Abstract: ROS (superoxide and oxygen peroxide in this paper) play a dual role as signalling molecules and strong oxidizing agents leading to oxidative stress. Their production mainly occurs in mitochondria although they may have other locations… read more here.
Keywords: ros production; respiratory chain; production; mitochondrial ros ... See more keywords
Increased RyR2 activity is exacerbated by calcium leak-induced mitochondrial ROS
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DOI: 10.1007/s00395-020-0797-z
Abstract: Cardiac disease is associated with deleterious emission of mitochondrial reactive oxygen species (mito-ROS), as well as enhanced oxidation and activity of the sarcoplasmic reticulum (SR) Ca 2+ release channel, the ryanodine receptor (RyR2). The transfer… read more here.
Keywords: mitochondrial ros; ryr2; ros emission; activity ... See more keywords
Knocking down Stard3 decreases adipogenesis with decreased mitochondrial ROS in 3T3-L1 cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.06.030
Abstract: Start domain-containing protein 3 (Stard3) plays roles in intracellular cholesterol distribution, however, the role of Stard3 in the adipogenesis of 3T3-L1 preadipocytes remains unclear. We demonstrated that Stard3 expression was significantly increased during the adipogenesis… read more here.
Keywords: mitochondrial ros; stard3; adipogenesis; 3t3 cells ... See more keywords
Mitochondrial ROS overproduction impairs glutamatergic signaling in frontotemporal dementia
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.207
Abstract: Glutamatergic neurotransmission is essential for learning and memory but an overactivation of the pathway may lead to calcium overload, excitotoxicity and neuronal death. Together with this, oxidative stress and mitochondrial dysfunction are all relevant to… read more here.
Keywords: mitochondrial ros; frontotemporal dementia; ros; ros overproduction ... See more keywords
Pravastatin alleviates intracellular calcium dysregulation induced by Interleukin-6 via the mitochondrial ROS pathway in adult ventricular myocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2020.01.013
Abstract: Acute inflammation often contributes to the increased arrhythmogenesis in the cardiomyocytes. We investigated the protective effects of pravastatin on calcium disorders induced by acute administration of pro-inflammatory cytokines in isolated ventricular myocytes and its underlying… read more here.
Keywords: ros pathway; mitochondrial ros; ventricular myocytes; ca2 ... See more keywords
Increased mitochondrial ROS generation mediates the loss of the anti‐contractile effects of perivascular adipose tissue in high‐fat diet obese mice
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DOI: 10.1111/bph.13687
Abstract: Obesity is associated with structural and functional changes in perivascular adipose tissue (PVAT), favouring release of reactive oxygen species (ROS), vasoconstrictor and proinflammatory factors. The cytokine TNF‐α induces vascular dysfunction and is produced by PVAT.… read more here.
Keywords: mitochondrial ros; perivascular adipose; tissue; generation ... See more keywords
Mitochondrial ROS-Modulated mtDNA: A Potential Target for Cardiac Aging
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DOI: 10.1155/2020/9423593
Abstract: Mitochondrial DNA (mtDNA) damage is associated with the development of cardiovascular diseases. Cardiac aging plays a central role in cardiovascular diseases. There is accumulating evidence linking cardiac aging to mtDNA damage, including mtDNA mutation and… read more here.
Keywords: mitochondrial ros; mtdna damage; cardiac aging; target ... See more keywords
Mycophenolic Acid Induces the Intestinal Epithelial Barrier Damage through Mitochondrial ROS
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DOI: 10.1155/2022/4195699
Abstract: Mycophenolic acid (MPA) may cause gastrointestinal adverse effects by damaging the intestinal epithelial barrier, the underlying mechanisms remain elusive. Studies have demonstrated that oxidative stress caused by reactive oxygen species (ROS) is linked to tight… read more here.
Keywords: mitochondrial ros; barrier; mycophenolic acid; mpa ... See more keywords
Mitochondrial ROS Produced by Skeletal Muscle Mitochondria Promote the Decisive Signal for UPRmt Activation
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DOI: 10.1155/2022/7436577
Abstract: The mitochondrial unfolded protein response (UPRmt) can repair and remove misfolded or unfolded proteins in mitochondria and enhance mitochondrial protein homeostasis. Reactive oxygen species (ROS) produced by regular exercise is a crucial signal for promoting… read more here.
Keywords: mitochondrial ros; ros produced; skeletal muscle; muscle mitochondria ... See more keywords