Markers for Mitochondrial ROS Status.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1653-6_15
Abstract: Mitochondria actively participate in oxygenic metabolism and are one of the major sources of reactive oxygen species (ROS) production in plant cells. However, instead of measuring ROS concentrations in organelles it is more worthwhile to… read more here.
Keywords: mitochondrial ros; production; ros; ros status ... See more keywords
Measurement of Mitochondrial ROS Formation.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7831-1_24
Abstract: Reactive oxygen species (ROS) are involved in both physiological and pathological processes. This widely accepted concept is based more on the effects of antioxidant interventions than on reliable assessments of rates and sites of intracellular… read more here.
Keywords: ros formation; mitochondrial ros; measurement mitochondrial; formation ... See more keywords
Modelling mitochondrial ROS production by the respiratory chain
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03381-1
Abstract: ROS (superoxide and oxygen peroxide in this paper) play a dual role as signalling molecules and strong oxidizing agents leading to oxidative stress. Their production mainly occurs in mitochondria although they may have other locations… read more here.
Keywords: ros production; respiratory chain; production; mitochondrial ros ... See more keywords
Increased RyR2 activity is exacerbated by calcium leak-induced mitochondrial ROS
Sign Up to like & getrecommendations! Published in 2020 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-020-0797-z
Abstract: Cardiac disease is associated with deleterious emission of mitochondrial reactive oxygen species (mito-ROS), as well as enhanced oxidation and activity of the sarcoplasmic reticulum (SR) Ca 2+ release channel, the ryanodine receptor (RyR2). The transfer… read more here.
Keywords: mitochondrial ros; ryr2; ros emission; activity ... See more keywords
Knocking down Stard3 decreases adipogenesis with decreased mitochondrial ROS in 3T3-L1 cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.06.030
Abstract: Start domain-containing protein 3 (Stard3) plays roles in intracellular cholesterol distribution, however, the role of Stard3 in the adipogenesis of 3T3-L1 preadipocytes remains unclear. We demonstrated that Stard3 expression was significantly increased during the adipogenesis… read more here.
Keywords: mitochondrial ros; stard3; adipogenesis; 3t3 cells ... See more keywords
Mitochondrial ROS overproduction impairs glutamatergic signaling in frontotemporal dementia
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.207
Abstract: Glutamatergic neurotransmission is essential for learning and memory but an overactivation of the pathway may lead to calcium overload, excitotoxicity and neuronal death. Together with this, oxidative stress and mitochondrial dysfunction are all relevant to… read more here.
Keywords: mitochondrial ros; frontotemporal dementia; ros; ros overproduction ... See more keywords
Pravastatin alleviates intracellular calcium dysregulation induced by Interleukin-6 via the mitochondrial ROS pathway in adult ventricular myocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2020.01.013
Abstract: Acute inflammation often contributes to the increased arrhythmogenesis in the cardiomyocytes. We investigated the protective effects of pravastatin on calcium disorders induced by acute administration of pro-inflammatory cytokines in isolated ventricular myocytes and its underlying… read more here.
Keywords: ros pathway; mitochondrial ros; ventricular myocytes; ca2 ... See more keywords
Macrophage MAPK7/AhR/STAT3 Signaling Mediates Mitochondrial ROS Burst and Enterohepatic Inflammatory Responses Induced by Deoxynivalenol Relevant to Low-Dose Exposure in Children.
Sign Up to like & getrecommendations! Published in 2024 at "Environmental science & technology"
DOI: 10.1021/acs.est.4c05875
Abstract: Deoxynivalenol (DON) can induce endoplasmic reticulum (ER) stress, mitochondrial ROS burst, and macrophage polarization. Here, we investigated the mechanism linking the above three aspects with the dose range relevant to low-level exposure in children. At… read more here.
Keywords: mapk7 ahr; ros burst; exposure; inflammatory responses ... See more keywords
#736 Defective autophagy drives ferroptosis via mitochondrial ROS in diabetic kidney disease
Sign Up to like & getrecommendations! Published in 2025 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaf116.0996
Abstract: Ferroptosis is a regulated form of cell death triggered by excessive lipid peroxidation and plays a crucial role in the pathogenesis of acute kidney injury (AKI). While autophagy has been shown to drive ferroptotic cell… read more here.
Keywords: mice; defective autophagy; ferroptosis; injury ... See more keywords
Deferasirox, an iron chelator, impacts myeloid differentiation by modulating NF‐kB activity via mitochondrial ROS
Sign Up to like & getrecommendations! Published in 2024 at "British Journal of Haematology"
DOI: 10.1111/bjh.19782
Abstract: The iron chelator deferasirox (DFX) is effective in the treatment of iron overload. In certain patients with myelodysplastic syndrome, DFX can also provide a dramatic therapeutic benefit, improving red blood cell production and decreasing transfusion… read more here.
Keywords: differentiation; iron; iron chelator; mitochondrial ros ... See more keywords
Increased mitochondrial ROS generation mediates the loss of the anti‐contractile effects of perivascular adipose tissue in high‐fat diet obese mice
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13687
Abstract: Obesity is associated with structural and functional changes in perivascular adipose tissue (PVAT), favouring release of reactive oxygen species (ROS), vasoconstrictor and proinflammatory factors. The cytokine TNF‐α induces vascular dysfunction and is produced by PVAT.… read more here.
Keywords: mitochondrial ros; perivascular adipose; tissue; generation ... See more keywords