Mitochondrial serine hydroxymethyltransferase 2 is a potential diagnostic and prognostic biomarker for human glioma
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2017.01.005
Abstract: OBJECTIVE Scholars have gradually come to appreciate the relevance of serine and glycine metabolism. Recently, researchers have discovered that mitochondrial serine hydroxymethyltransferase 2 (SHMT2) is overexpressed in various types of cancer. However, the function of… read more here.
Keywords: expression shmt2; mitochondrial serine; glioma; shmt2 ... See more keywords
Mitochondrial serine transporter identified
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.362.6416.788-j
Abstract: Cell Metabolism One-carbon (1C) metabolism is a universal metabolic process that is required for purine synthesis and supports the high levels of proliferation in cancer cells. The transport of serine into mitochondria supplies most of… read more here.
Keywords: metabolism; serine transporter; mitochondrial serine; transporter identified ... See more keywords
Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-19-0606
Abstract: Breast cancer is the most common cancer among American women and a major cause of mortality. To identify metabolic pathways as potential targets to treat metastatic breast cancer, we performed metabolomics profiling on the breast… read more here.
Keywords: unit; breast cancer; mitochondrial serine; cancer ... See more keywords