ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2018355118
Abstract: Significance Although formation of the mitochondrial sheath is a critical process in the formation of mature spermatozoa, the molecular mechanisms involved in mitochondrial sheath genesis remain unclear. Using gene-manipulated mice, we discovered that ARMC12 regulates… read more here.
Keywords: sheath formation; mitochondrial dynamics; sheath; mitochondrial sheath ... See more keywords
TBC1D21 is an essential factor for sperm mitochondrial sheath assembly and male fertility.
Sign Up to like & getrecommendations! Published in 2022 at "Biology of reproduction"
DOI: 10.1093/biolre/ioac069
Abstract: During spermiogenesis, the formation of the mitochondrial sheath is critical for male fertility. The molecular processes that govern the development of the mitochondrial sheath remain unknown. Whether TBC1D21 serves as a GTPase-activating protein (GAP) for… read more here.
Keywords: sheath; mice; male fertility; tbc1d21 ... See more keywords
CFAP65 is required in the acrosome biogenesis and mitochondrial sheath assembly during spermiogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Human molecular genetics"
DOI: 10.1093/hmg/ddab185
Abstract: Asthenoteratospermia is a common cause of male infertility. Recent studies have revealed that CFAP65 mutations lead to severe asthenoteratospermia due to acrosome hypoplasia and flagellum malformations. However, the molecular mechanism underlying CFAP65-associated sperm malformation is… read more here.
Keywords: cfap65; spermiogenesis; acrosome biogenesis; mitochondrial sheath ... See more keywords
Novel FSIP2 Variants Induce Super-Length Mitochondrial Sheath and Asthenoteratozoospermia in Humans
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.76051
Abstract: Asthenoteratozoospermia is one of the major factors for male infertility, whereas the causes of large numbers of cases are still unknown. We identified compound heterozygous variants of FSIP2 in three unrelated individuals from a cohort… read more here.
Keywords: super length; novel fsip2; sheath; mitochondrial sheath ... See more keywords