Targeting eIF5A Hypusination Prevents Anoxic Cell Death through Mitochondrial Silencing and Improves Kidney Transplant Outcome.
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DOI: 10.1681/asn.2016010012
Abstract: The eukaryotic initiation factor 5A (eIF5A), which is highly conserved throughout evolution, has the unique characteristic of post-translational activation through hypusination. This modification is catalyzed by two enzymatic steps involving deoxyhypusine synthase (DHPS) and deoxyhypusine… read more here.
Keywords: mitochondrial silencing; kidney transplant; eif5a hypusination; gc7 ... See more keywords