Mitochondrial sirtuins genetic variations and gastric cancer risk: evidence from retrospective observational study.
Sign Up to like & getrecommendations! Published in 2021 at "Gene"
DOI: 10.1016/j.gene.2021.145951
Abstract: AIMS The purpose of the present study was to analyze the role of selected polymorphisms of SIRT3 and SIRT5 in gastric carcinogenesis. METHODS For this study, 500 blood samples of GC patients and 500 blood… read more here.
Keywords: sirtuins genetic; risk; mitochondrial sirtuins; selected polymorphisms ... See more keywords
Mitochondrial Sirtuins and Molecular Mechanisms of Aging.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2017.02.005
Abstract: Advancing age is the major risk factor for the development of chronic diseases and is accompanied by changes in metabolic processes and mitochondrial dysfunction. Mitochondrial sirtuins (SIRT3-5) are part of the sirtuin family of NAD+-dependent… read more here.
Keywords: medicine; age; mitochondrial sirtuins; sirtuins molecular ... See more keywords
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01215
Abstract: Sirtuins are NAD+-dependent protein deacylases involved in metabolic regulation and aging-related diseases. Specific activators for seven human Sirtuin isoforms would be important chemical tools and potential therapeutic drugs. Activators have been described for Sirt1 and… read more here.
Keywords: sirt3 sirt5; mitochondrial sirtuins; activators mitochondrial; specific activators ... See more keywords
Oncometabolic role of mitochondrial sirtuins in glioma patients
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0281840
Abstract: Mitochondrial sirtuins have diverse role specifically in aging, metabolism and cancer. In cancer, these sirtuins play dichotomous role as tumor suppressor and promoter. Previous studies have reported the involvement of sirtuins in different cancers. However,… read more here.
Keywords: mitochondrial sirtuins; oncometabolic role; level; glioma patients ... See more keywords
Targeting Mitochondrial Sirtuins in Age-Related Neurodegenerative Diseases and Fibrosis.
Sign Up to like & getrecommendations! Published in 2023 at "Aging and disease"
DOI: 10.14336/ad.2023.0203
Abstract: Aging is a natural and complex biological process that is associated with widespread functional declines in numerous physiological processes, terminally affecting multiple organs and tissues. Fibrosis and neurodegenerative diseases (NDs) often occur with aging, imposing… read more here.
Keywords: age related; disease; mitochondrial sirtuins; targeting mitochondrial ... See more keywords
Roles of Mitochondrial Sirtuins in Mitochondrial Function, Redox Homeostasis, Insulin Resistance and Type 2 Diabetes
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21155266
Abstract: Mitochondria are the metabolic hubs that process a number of reactions including tricarboxylic acid cycle, β-oxidation of fatty acids and part of the urea cycle and pyrimidine nucleotide biosynthesis. Mitochondrial dysfunction impairs redox homeostasis and… read more here.
Keywords: insulin; mitochondrial sirtuins; type diabetes; resistance type ... See more keywords
Mitochondrial Sirtuins in Chronic Degenerative Diseases: New Metabolic Targets in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23063212
Abstract: Sirtuins (SIRTs) are a family of class III histone deacetylases (HDACs) consisting of seven members, widely expressed in mammals. SIRTs mainly participate in metabolic homeostasis, DNA damage repair, cell survival, and differentiation, as well as… read more here.
Keywords: cancer; degenerative diseases; chronic degenerative; mitochondrial sirtuins ... See more keywords