CDCP1/mitochondrial Src axis increases electron transport chain function to promote metastasis in triple-negative breast cancer
Sign Up to like & getrecommendations! Published in 2025 at "British Journal of Cancer"
DOI: 10.1038/s41416-025-03163-6
Abstract: Triple-negative type of breast cancer (TNBC) has limited therapeutic options and frequently metastasizes, leading to low survival rates. Oxidative phosphorylation (OXPHOS) is a driver of TNBC metastasis, but the signaling underlying this metabolic change is… read more here.
Keywords: cancer; cdcp1 mitochondrial; mitochondrial src; triple negative ... See more keywords
The NLRP3 Inflammasome Works as a Sensor for Detecting Hypoactivity of the Mitochondrial Src Family Kinases.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of immunology"
DOI: 10.4049/jimmunol.2200611
Abstract: Gefitinib (GF), the tyrosine kinase inhibitor (TKI) targeting epidermal growth factor receptor, initiates lung inflammation through the NLR family pyrin domain containing 3 (NLRP3) inflammasome. However, the molecular targets and mechanisms underlying the inflammatory action… read more here.
Keywords: hypoactivity; family; mitochondrial src; family kinases ... See more keywords