Mitochondrial STAT3 regulates antioxidant gene expression through complex I‐derived NAD in triple negative breast cancer
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DOI: 10.1002/1878-0261.12928
Abstract: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor with roles in inflammation and tumorigenicity. A fraction of STAT3 localizes in mitochondria, where it augments tumorigenesis via regulation of mitochondrial functions, including… read more here.
Keywords: stat3; mitochondrial stat3; expression; antioxidant gene ... See more keywords
A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function
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DOI: 10.3390/ijms19061656
Abstract: Stat3 as a transcription factor regulating gene expression in lymphocytes during the immune response is well known. However, since the pioneering studies discovering the presence of Stat3 in mitochondria and its role in regulating mitochondrial… read more here.
Keywords: stat3; stat3 regulator; mitochondrial stat3; function ... See more keywords
Analysis of Radiation Toxicity in Mammalian Cells Stably Transduced with Mitochondrial Stat3
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DOI: 10.3390/ijms24098232
Abstract: A coordinated action between nuclear and mitochondrial activities is essential for a proper cellular response to genotoxic stress. Several nuclear transcription factors, including STAT3, translocate to mitochondria to exert mitochondrial function regulation; however, the role… read more here.
Keywords: mitochondrial stat3; cells stably; stat3; stably transduced ... See more keywords
Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation
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DOI: 10.7150/thno.63751
Abstract: Rationale: We found that a subset of signal transducer and activator of transcription 3 (STAT3) translocated into mitochondria in phagocytes, including macrophages isolated from individuals with sepsis. However, the role of mitochondrial STAT3 in macrophages… read more here.
Keywords: mitochondrial stat3; cpt1a; induced sepsis; stat3 ... See more keywords