Conserved nicotine-activated neuroprotective pathways involve mitochondrial stress
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102140
Abstract: Summary Tobacco smoking is a risk factor for several human diseases. Conversely, smoking also reduces the prevalence of Parkinson’s disease, whose hallmark is degeneration of substantia nigra dopaminergic neurons (DNs). We use C. elegans as… read more here.
Keywords: conserved nicotine; activated neuroprotective; neuroprotective pathways; mitochondrial stress ... See more keywords
Mitochondrial Stress Induced p53 Attenuates HIF-1α Activity by Physical Association and Enhanced Ubiquitination
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.211
Abstract: Retrograde signaling is a mechanism by which mitochondrial dysfunction is communicated to the nucleus for inducing a metabolic shift essential for cell survival. Previously, we showed that partial mitochondrial DNA (mtDNA) depletion in different cell… read more here.
Keywords: hif; mitochondrial stress; stress induced; stress ... See more keywords
Memory of ancestral mitochondrial stress
Sign Up to like & getrecommendations! Published in 2018 at "Nature Cell Biology"
DOI: 10.1038/s41556-018-0255-4
Abstract: Ancestral experience of mitochondrial stress is now found to render progeny of the roundworm Caenorhabditis elegans more resistant to the same insult for up to four generations. A DNA modification, N6-methyldeoxyadenine, is implicated in the… read more here.
Keywords: memory ancestral; ancestral mitochondrial; mitochondrial stress; stress ... See more keywords
Proteomic analysis of plasma extracellular vesicles reveals mitochondrial stress upon HTLV-1 infection
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-23505-0
Abstract: Extracellular vesicles (EVs) can participate in intercellular communication and pathogenesis. EVs contain many cargos, including proteins, and the composition of EVs differs between cell-types and activation levels. Thus, plasma EVs can be used as a… read more here.
Keywords: htlv; extracellular vesicles; plasma; infection ... See more keywords
Multi-omics analyses reveal early metabolic imbalance and mitochondrial stress in neonatal photoreceptors leading to cell death in Pde6brd1/rd1 mouse model of retinal degeneration.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac013
Abstract: Retinal diseases exhibit extensive genetic heterogeneity and complex etiology with varying onset and severity. Mutations in over 200 genes can lead to photoreceptor dysfunction and/or cell death in retinal neurodegeneration. To deduce molecular pathways that… read more here.
Keywords: cell death; cell; degeneration; rd1 ... See more keywords
NuRD mediates mitochondrial stress–induced longevity via chromatin remodeling in response to acetyl-CoA level
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.abb2529
Abstract: Acetyl-CoA links mitochondrial stress to the nuclear epigenome via NuRD complex for life-span regulation. Mild mitochondrial stress experienced early in life can have beneficial effects on the life span of organisms through epigenetic regulations. Here,… read more here.
Keywords: chromatin; acetyl coa; stress; mitochondrial stress ... See more keywords
FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn7105
Abstract: The mitochondrial integrated stress response (mitoISR) has emerged as a major adaptive pathway to respiratory chain deficiency, but both the tissue specificity of its regulation, and how mitoISR adapts to different levels of mitochondrial dysfunction… read more here.
Keywords: stress response; mitochondrial dysfunction; dysfunction; mitoisr ... See more keywords
Mitochondrial Stress in Metabolic Inflammation: Modest Benefits and Full Losses
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/8803404
Abstract: Energy intake and metabolic balance are the pillars of health preservation. Overnutrition causes nonspecific, persistently low inflammatory state known as metabolic inflammation. This condition contributes to the pathophysiology of various metabolic disorders, such as atherosclerosis,… read more here.
Keywords: inflammation; stress metabolic; metabolic inflammation; mitochondrial dysfunction ... See more keywords
Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.155147
Abstract: Muscle weakness and wasting are defining features of cancer-induced cachexia. Mitochondrial stress occurs before atrophy in certain muscles, but the possibility of heterogeneous responses between muscles and across time remains unclear. Using mice inoculated with… read more here.
Keywords: muscle; muscle weakness; force; mitochondrial stress ... See more keywords
Role of the mitochondrial stress response in human cancer progression
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Biology and Medicine"
DOI: 10.1177/1535370220920558
Abstract: Mitochondria are important organelles that are responsible for cellular energy metabolism, cellular redox/calcium homeostasis, and cell death regulation in mammalian cells. Mitochondrial dysfunction is involved in various diseases, such as neurodegenerative diseases, cardiovascular diseases, immune… read more here.
Keywords: mitochondrial stress; stress response; cancer progression; cancer ... See more keywords
Bendless is essential for PINK1-Park mediated Mitofusin degradation under mitochondrial stress caused by loss of LRPPRC
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1010493
Abstract: Cells under mitochondrial stress often co-opt mechanisms to maintain energy homeostasis, mitochondrial quality control and cell survival. A mechanistic understanding of such responses is crucial for further insight into mitochondrial biology and diseases. Through an… read more here.
Keywords: degradation; pink1; mitochondrial stress; pink1 park ... See more keywords