The Effect of 2-Ketobutyrate on Mitochondrial Substrate-Level Phosphorylation
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemical Research"
DOI: 10.1007/s11064-019-02759-8
Abstract: The reaction catalyzed by succinate-CoA ligase in the mitochondrial matrix yields a high-energy phosphate when operating towards hydrolysis of the thioester bond of succinyl-CoA, known as mitochondrial substrate-level phosphorylation (mSLP). The catabolism of several metabolites… read more here.
Keywords: ketobutyrate; succinyl coa; substrate level; coa ... See more keywords
Intact mitochondrial substrate efflux is essential to prevent tubular injury in a sex-dependent manner.
Sign Up to like & getrecommendations! Published in 2022 at "JCI insight"
DOI: 10.1172/jci.insight.150696
Abstract: The importance of healthy mitochondrial function is implicated in the prevention of chronic/diabetic kidney diseases (CKD/DKD). Sex differences also play an important role in DKD. Our previous studies revealed that mitochondrial substrate overload (modeled by… read more here.
Keywords: intact mitochondrial; injury; substrate efflux; mitochondrial substrate ... See more keywords
Targeting Mitochondrial Biogenesis and Mitochondrial Substrate Utilization to Treat Obesity and Insulin Resistance, Respectively - Two Data-Driven Hypotheses.
Sign Up to like & getrecommendations! Published in 2017 at "Current diabetes reviews"
DOI: 10.2174/1573399812666160217122827
Abstract: INTRODUCTION The mitochondrion plays a critical role in cellular energy metabolism. For this reason it is considered as a plausible target for the treatment of metabolic diseases such as obesity and type-2 diabetes. Although several… read more here.
Keywords: mitochondrial biogenesis; treat; substrate utilization; obesity ... See more keywords