Low concentrations of bisphenol A promote the activation of the mitochondrial apoptotic pathway on Beta‐TC‐6 cells via the generation of intracellular reactive oxygen species and mitochondrial superoxide
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23099
Abstract: Τhe natural history of type 2 diabetes mellitus is characterized by a progressive loss of pancreatic beta cell function and insulin resistance. Bisphenol A (BPA) is an endocrine‐disrupting chemical that is used widely in industry;… read more here.
Keywords: reactive oxygen; species mitochondrial; beta; oxygen species ... See more keywords
Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function.
Sign Up to like & getrecommendations! Published in 2017 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2016_117
Abstract: Mitochondria are a major source of intracellular energy and reactive oxygen species in cells, but are also increasingly being recognized as a controller of cell death. Here, we review evidence of signal transduction control by… read more here.
Keywords: reactive oxygen; oxygen species; mitochondrial superoxide; mitochondrial reactive ... See more keywords
Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion
Sign Up to like & getrecommendations! Published in 2019 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-019-0726-1
Abstract: We and others have reported that calpain-1 was increased in myocardial mitochondria from various animal models of heart disease. This study investigated whether constitutive up-regulation of calpain-1 restricted to mitochondria induced myocardial injury and heart… read more here.
Keywords: calpain; heart; mitochondrial superoxide; heart failure ... See more keywords
Switch of Mitochondrial Superoxide Dismutase into a Prooxidant Peroxidase in Manganese-Deficient Cells and Mice.
Sign Up to like & getrecommendations! Published in 2018 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.01.007
Abstract: Superoxide radical anion (O2⋅‒) and other reactive oxygen species are constantly produced during respiration. In mitochondria, the dismutation of O2⋅‒ is accelerated by the mitochondrial superoxide dismutase 2 (SOD2), an enzyme that has been traditionally associated… read more here.
Keywords: peroxidase; prooxidant peroxidase; mitochondrial superoxide; superoxide dismutase ... See more keywords
Mitochondrial Superoxide Dismutase Specifies Early Neural Commitment by Modulating Mitochondrial Dynamics
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101564
Abstract: Summary Studies revealing molecular mechanisms underlying neural specification have majorly focused on the role played by different transcription factors, but less on non-nuclear components. Earlier, we reported mitochondrial superoxide dismutase (SOD2) to be essential for… read more here.
Keywords: mitochondrial superoxide; modulating mitochondrial; early neural; mitochondrial dynamics ... See more keywords
Methionine Ameliorates Polymyxin-Induced Nephrotoxicity by Attenuating Cellular Oxidative Stress
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01254-17
Abstract: ABSTRACT Polymyxins are a last line of defense against multidrug-resistant Gram-negative pathogens. Recent pharmacological data show that intravenous polymyxins can cause nephrotoxicity in up to 60% of patients, and the plasma concentrations of polymyxins achieved… read more here.
Keywords: polymyxin induced; induced nephrotoxicity; methionine; mitochondrial superoxide ... See more keywords
RIP3-Dependent Accumulation of Mitochondrial Superoxide Anions in TNF-α-Induced Necroptosis
Sign Up to like & getrecommendations! Published in 2022 at "Molecules and Cells"
DOI: 10.14348/molcells.2021.0260
Abstract: Excessive production of reactive oxygen species (ROS) is a key phenomenon in tumor necrosis factor (TNF)-α-induced cell death. However, the role of ROS in necroptosis remains mostly elusive. In this study, we show that TNF-α… read more here.
Keywords: superoxide anions; necroptosis; tnf induced; mitochondrial superoxide ... See more keywords
Docosahexaenoic Acid Potentiates the Anticancer Effect of the Menadione/Ascorbate Redox Couple by Increasing Mitochondrial Superoxide and Accelerating ATP Depletion
Sign Up to like & getrecommendations! Published in 2023 at "AntiCancer Research"
DOI: 10.21873/anticanres.16268
Abstract: Background/Aim: Mitochondria-targeted anticancer drugs (“mitocans”) of natural origin are attractive candidates as adjuvants in cancer therapy. The redox couple menadione/ascorbate (M/A), which belongs to the “mitocans” family, induces selective oxidative stress in cancerous mitochondria and… read more here.
Keywords: superoxide; mitochondrial superoxide; menadione; anticancer effect ... See more keywords
Coupling of phagocytic NADPH oxidase activity and mitochondrial superoxide production
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.942736
Abstract: Superoxide radical plays an important role in redox cell signaling and physiological processes; however, overproduction of superoxide or insufficient activity of antioxidants leads to oxidative stress and contributes to the development of pathological conditions such… read more here.
Keywords: superoxide; mitochondrial superoxide; nadph oxidase; superoxide production ... See more keywords
Prostaglandin E2 Signals Through E Prostanoid Receptor 2 to Inhibit Mitochondrial Superoxide Formation and the Ensuing Downstream Cytotoxic and Genotoxic Effects Induced by Arsenite
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00781
Abstract: We investigated the effects of prostaglandin E2 (PGE2), an important inflammatory lipid mediator, on the cytotoxicity–genotoxicity induced by arsenite. With the use of a toxicity paradigm in which the metalloid uniquely induces mitochondrial superoxide (mitoO2… read more here.
Keywords: prostanoid receptor; induced arsenite; mitochondrial superoxide; formation ... See more keywords
Elucidating the Role of Toxoplasma gondii’s Mitochondrial Superoxide Dismutase
Sign Up to like & getrecommendations! Published in 2025 at "Biomolecules"
DOI: 10.3390/biom15070972
Abstract: Toxoplasma gondii is an Apicomplexan parasite that possesses a well-developed system of scavengers of reactive oxygen species (ROS). Among its components, T. gondii mitochondrial superoxide dismutase (TgSOD2) is essential, as predicted by the CRISPR phenotype… read more here.
Keywords: toxoplasma gondii; role; superoxide dismutase; mitochondrial superoxide ... See more keywords