Smart mitochondrial‐targeted cancer therapy: Subcellular distribution, selective TrxR2 inhibition accompany with declined antioxidant capacity
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.11.057
Abstract: Graphical abstract Figure. No caption available. Abstract Targeting mitochondrial redox homeostasis is an appealing methodology for cancer therapeutics because of the upregulated antioxidant capacity in drug resistance cases. By coupling triphenylamine (TPA) with an excellent… read more here.
Keywords: cancer; mitochondrial targeted; antioxidant capacity; distribution ... See more keywords
Mitochondrial-targeted ubiquinone alleviates concanavalin A-induced hepatitis via immune modulation.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106518
Abstract: BACKGROUND Despite knowledge regarding the effects of antioxidants in ameliorating oxidative damage, evidence concerning their effects on activated immune cells is lacking. Here, a concanavalin A (Con A)-induced hepatitis mouse model was used to investigate… read more here.
Keywords: modulation; hepatitis; con; mitochondrial targeted ... See more keywords
Development of mitochondrial targeted theranostic nanocarriers for treatment of gliomas
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2021.102648
Abstract: Abstract Theranostic nanoparticles were developed using synthesized Gadolinium doped iron oxide nanoplatforms by polyol process. Lenalidomide was coated on the magnetic core using PLGA by nanoprecipitation technique. Modification of Polyethylenimine was done with targeting moieties… read more here.
Keywords: mitochondrial targeted; targeted theranostic; theranostic nanocarriers; nanocarriers treatment ... See more keywords
Mitochondrial targeted rhodium(III) complexes: Synthesis, characterized and antitumor mechanism investigation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2021.111400
Abstract: Recently, rhodium complexes have received intensive attentions due to their tunable chemical and biological properties as well as attractive antitumor activity. In this work, two imidazole triphenylamino rhodium complexes [Rh(ppy)2L1]PF6 (Rh1) and [Rh(ppy)2L2]PF6 (Rh2) (ppy = 2-phenylpyridine,… read more here.
Keywords: mechanism; rhodium; rhodium complexes; targeted rhodium ... See more keywords
Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23561-7
Abstract: Diseases caused by heteroplasmic mitochondrial DNA mutations have no effective treatment or cure. In recent years, DNA editing enzymes were tested as tools to eliminate mutant mtDNA in heteroplasmic cells and tissues. Mitochondrial-targeted restriction endonucleases,… read more here.
Keywords: eliminate mutant; meganuclease; mtdna; mitochondrial targeted ... See more keywords
Development of a mitochondrial-targeted two-photon fluorescence turn-on probe for formaldehyde and its bio-imaging applications in living cells and tissues
Sign Up to like & getrecommendations! Published in 2018 at "New Journal of Chemistry"
DOI: 10.1039/c8nj01240g
Abstract: A mitochondrial-targeted two-photon fluorescent formaldehyde probe (MT-FA) with a large emission enhancement was developed. MT-FA could image formaldehyde in the mitochondria of living cells for the first time, and also could image formaldehyde in living… read more here.
Keywords: probe; two photon; mitochondrial targeted; targeted two ... See more keywords
Mitochondrial targeted doxorubicin derivatives delivered by ROS-responsive nanocarriers to breast tumor for overcoming of multidrug resistance
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2020.1832116
Abstract: Abstract Multidrug resistance (MDR) is a serious challenge in chemotherapy and also a major threat to breast cancer treatment. As an intracellular energy factory, mitochondria provide energy for drug efflux and are deeply involved in… read more here.
Keywords: doxorubicin derivatives; mitochondrial targeted; multidrug resistance; ros responsive ... See more keywords
Mitochondrial targeted peptides preserve mitochondrial organization and decrease reversible myocardial changes in early swine metabolic syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvx245
Abstract: Aims The mechanisms responsible for cardiac damage in the early stages of metabolic syndrome (MetS) remain unknown. Mitochondria are intimately associated with cellular myofibrils, with the cytoskeleton functioning as a linkage coordinator, and closely associated… read more here.
Keywords: changes early; mitochondrial targeted; mitochondrial organization; metabolic syndrome ... See more keywords
Mitochondrial-targeted antioxidant attenuates preeclampsia-like phenotypes induced by syncytiotrophoblast-specific Gq signaling
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732356
Abstract: Generalized cellular ‘stress’ (i.e., oxidative, mitochondrial) within the syncytiotrophoblast (STB) layer of placenta is theorized to drive the pathogenesis of preeclampsia (PE), but the causes and consequences of this stress have yet to be clearly… read more here.
Keywords: cre; targeted antioxidant; specific signaling; physiology ... See more keywords
Mitochondrial targeted fluorescent nitrite peroxide probe for dynamic monitoring of cellular lung injury.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical biochemistry"
DOI: 10.2139/ssrn.4135991
Abstract: Herein, a mitochondrial targeted fluorescent nitrite peroxide probe CHP for dynamic monitoring of cellular lung injury was developed. For the practical delivery and selectivity, the structural features including pyridine head and borate recognition group were… read more here.
Keywords: targeted fluorescent; cellular lung; mitochondrial targeted; lung injury ... See more keywords
Mitochondrial-Targeted Ratiometric Fluorescent Probe to Monitor ClO− Induced by Ferroptosis in Living Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.909670
Abstract: Ferroptosis is a type of iron-dependent programmed cell death. Once such kind of death occurs, an individual cell would undergo a series of changes related to reactive oxygen species (ROS) in mitochondria. A mitochondrial-targeted ratiometric… read more here.
Keywords: mbi ome; mitochondrial targeted; fluorescent probe; ferroptosis ... See more keywords