The TFAMoplex—Conversion of the Mitochondrial Transcription Factor A into a DNA Transfection Agent
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104987
Abstract: Non‐viral gene delivery agents, such as cationic lipids, polymers, and peptides, mainly rely on charge‐based and hydrophobic interactions for the condensation of DNA molecules into nanoparticles. The human protein mitochondrial transcription factor A (TFAM), on… read more here.
Keywords: dna; transfection agent; mitochondrial transcription; transcription factor ... See more keywords
Mitochondrial transcription factor A plays opposite roles in the initiation and progression of colitis‐associated cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Communications"
DOI: 10.1002/cac2.12184
Abstract: Mitochondria are key regulators in cell proliferation and apoptosis. Alterations in mitochondrial function are closely associated with inflammation and tumorigenesis. This study aimed to investigate whether mitochondrial transcription factor A (TFAM), a key regulator of… read more here.
Keywords: transcription; initiation progression; mitochondrial transcription; transcription factor ... See more keywords
Characterization of Bombyx mori mitochondrial transcription factor A, a conserved regulator of mitochondrial DNA.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2016.12.021
Abstract: In the present study, we initially cloned and characterized a mitochondrial transcription factor A (Tfam) homologue in the silkworm, Bombyx mori. Bombyx mori TFAM (BmTFAM) localized to mitochondria in cultured silkworm and human cells, and… read more here.
Keywords: bombyx mori; bmtfam; bombyx; mitochondrial transcription ... See more keywords
Mitochondrial transcription factor A (TFAM) rs1937 and AP endonuclease 1 (APE1) rs1130409 alleles are associated with reduced cognitive performance
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.02.062
Abstract: Mitochondrial dysfunction and DNA damage is intimately connected to ageing and neurodegeneration, including Alzheimer's disease (AD). A particular culprit in this context is oxidative stress, which is a result of increased reactive oxygen species (ROS)… read more here.
Keywords: tfam rs1937; ape1 rs1130409; factor tfam; mitochondrial transcription ... See more keywords
Key Amino Acid Residues of Mitochondrial Transcription Factor A Synergize with Abasic (AP) Site Dynamics To Facilitate AP-Lyase Reactions.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical biology"
DOI: 10.1021/acschembio.3c00047
Abstract: Human mitochondrial DNA (mtDNA) encodes 37 essential genes and plays a critical role in mitochondrial and cellular functions. mtDNA is susceptible to damage by endogenous and exogenous chemicals. Damaged mtDNA molecules are counteracted by the… read more here.
Keywords: dna; facilitate lyase; lyase reactions; factor ... See more keywords
Starting the engine of the powerhouse: mitochondrial transcription and beyond
Sign Up to like & getrecommendations! Published in 2022 at "Biological Chemistry"
DOI: 10.1515/hsz-2021-0416
Abstract: Abstract Mitochondria are central hubs for cellular metabolism, coordinating a variety of metabolic reactions crucial for human health. Mitochondria provide most of the cellular energy via their oxidative phosphorylation (OXPHOS) system, which requires the coordinated… read more here.
Keywords: engine powerhouse; transcription; expression; mitochondrial transcription ... See more keywords
Tissue specific splicing of pre-mRNA porcine mitochondrial transcription factor A
Sign Up to like & getrecommendations! Published in 2018 at "Czech Journal of Animal Science"
DOI: 10.17221/29/2017-cjas
Abstract: Renčelj A., Škrlep M., Čandek-Potokar M., Dovč P. (2018): Tissue specific splicing of pre-mRNA porcine mitochondrial transcription factor A. Czech J. Anim. Sci., 63, 43–50. Mitochondrial transcription factor A plays, due to its role in… read more here.
Keywords: transcription; tissue specific; mitochondrial transcription; transcription factor ... See more keywords
Novel interaction interfaces mediate the interaction between the NEIL1 DNA glycosylase and mitochondrial transcription factor A
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.893806
Abstract: The maintenance of human mitochondrial DNA (mtDNA) is critical for proper cellular function as damage to mtDNA, if left unrepaired, can lead to a diverse array of pathologies. Of the pathways identified to participate in… read more here.
Keywords: interaction; interaction neil1; dna; mitochondrial transcription ... See more keywords
Mitochondrial Transcription of Entomopathogenic Fungi Reveals Evolutionary Aspects of Mitogenomes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.821638
Abstract: Entomopathogenic fungi and more specifically genera Beauveria and Metarhizium have been exploited for the biological control of pests. Genome analyses are important to understand better their mode of action and thus, improve their efficacy against… read more here.
Keywords: fungi reveals; reveals evolutionary; transcription; mitochondrial transcription ... See more keywords
Targeting Mitochondrial DNA Transcription by POLRMT Inhibition or Depletion as a Potential Strategy for Cancer Treatment
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11061598
Abstract: Transcription of the mitochondrial genome is essential for the maintenance of oxidative phosphorylation (OXPHOS) and other functions directly related to this unique genome. Considerable evidence suggests that mitochondrial transcription is dysregulated in cancer and cancer… read more here.
Keywords: inhibition; polrmt; transcription; mitochondrial transcription ... See more keywords
Genome-Wide Identification and Characterization of the Mitochondrial Transcription Termination Factors (mTERFs) in Capsicum annuum L.
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21010269
Abstract: Mitochondrial transcription termination factors (mTERFs) regulate the expression of mitochondrial genes and are closely related to the function of the mitochondrion and chloroplast. In this study, the mTERF gene family in capsicum (Capsicum annuum L.)… read more here.
Keywords: transcription termination; capsicum annuum; termination factors; mitochondrial transcription ... See more keywords