Mitochondrial transfer from aged adipose‐derived stem cells does not improve the quality of aged oocytes in C57BL/6 mice
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23129
Abstract: Female fertility declines dramatically over the age of 35 due to age‐related decreases in oocyte quality and quantity. Although mitochondrial transfer promises to be a technology that can improve the quality of such age‐impaired oocytes,… read more here.
Keywords: quality; mitochondrial transfer; derived stem; stem cells ... See more keywords
Oxidative stress and mitochondrial transfer: A new dimension towards ocular diseases
Sign Up to like & getrecommendations! Published in 2020 at "Genes and Diseases"
DOI: 10.1016/j.gendis.2020.11.020
Abstract: Abstract Ocular cells like, retinal pigment epithelium (RPE) is a highly specialized pigmented monolayer of post-mitotic cells, which is located in the posterior segment of the eye between neuro sensory retina and vascular choroid. It… read more here.
Keywords: mitochondrial transfer; diseases oxidative; ocular diseases; stress ... See more keywords
Detection of mitochondrial transfer RNA (mt-tRNA) gene mutations in patients with idiopathic pulmonary fibrosis and sarcoidosis.
Sign Up to like & getrecommendations! Published in 2018 at "Mitochondrion"
DOI: 10.1016/j.mito.2018.10.004
Abstract: Mitochondrial reactive oxygen species production may lead to tissue injury associated with two respiratory disorders of unknown origin which are shared by common tissue fibrosis, IPF and sarcoidosis. Sequence analysis of 22 mt-tRNA genes and… read more here.
Keywords: mitochondrial transfer; fibrosis; ipf sarcoidosis; detection mitochondrial ... See more keywords
PGC-1α induced mitochondrial biogenesis in stromal cells underpins mitochondrial transfer to melanoma.
Sign Up to like & getrecommendations! Published in 2022 at "British journal of cancer"
DOI: 10.1038/s41416-022-01783-w
Abstract: INTRODUCTION Progress in the knowledge of metabolic interactions between cancer and its microenvironment is ongoing and may lead to novel therapeutic approaches. Until recently, melanoma was considered a glycolytic tumour due to mutations in mitochondrial-DNA,… read more here.
Keywords: mitochondrial transfer; melanoma cells; transfer; melanoma ... See more keywords
Mitochondrial transfer in BAT
Sign Up to like & getrecommendations! Published in 2022 at "Nature Reviews Endocrinology"
DOI: 10.1038/s41574-022-00674-7
Abstract: 0123456789();: Mitochondrial transfer between cells has been previously demonstrated to control metabolic homeostasis. Whether mitochondrial transfer occurs in brown adipose tissue (BAT) and has a role in adaptive thermogenesis was unclear. A new study in… read more here.
Keywords: bat; mitochondrial transfer; bat evs; thermogenesis ... See more keywords
Mesenchymal stem cells and their mitochondrial transfer: a double-edged sword
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20182417
Abstract: Mitochondrial dysfunction has been linked to many diseases including organ degeneration and cancer. Mesenchymal stem cells/stromal cells (MSCs) provide a valuable source for stem cell-based therapy and represent an emerging therapeutic approach for tissue regeneration.… read more here.
Keywords: mesenchymal stem; mitochondrial transfer; stem cells; cancer ... See more keywords
Stem cell therapy in brain ischemia-the role of mitochondrial transfer.
Sign Up to like & getrecommendations! Published in 2020 at "Stem cells and development"
DOI: 10.1089/scd.2019.0237
Abstract: Mitochondrial dysfunction is an important pathological process in the setting of ischemic brain injury. Stem cell-mediated mitochondrial transfer provides an efficient intercellular process to supply additional mitochondria in the ischemic brain tissues. In this review,… read more here.
Keywords: mitochondrial transfer; brain ischemia; stem cell; stem ... See more keywords
Mesenchymal Stromal Cell Mitochondrial Transfer as a Cell Rescue Strategy in Regenerative Medicine: A Review of Evidence in Preclinical Models
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells Translational Medicine"
DOI: 10.1093/stcltm/szac044
Abstract: Abstract Mesenchymal stromal cells (MSC) have excellent clinical potential and numerous properties that ease its clinical translation. Mitochondria play a crucial role in energy metabolism, essential for cellular activities, such as proliferation, differentiation, and migration.… read more here.
Keywords: cell; mesenchymal stromal; review; mitochondrial transfer ... See more keywords
Intercellular mitochondrial transfer alleviates pyroptosis in dental pulp damage.
Sign Up to like & getrecommendations! Published in 2023 at "Cell proliferation"
DOI: 10.1111/cpr.13442
Abstract: Mitochondrial transfer is emerging as a promising therapeutic strategy for tissue repair, but whether it protects against pulpitis remains unclear. Here, we show that hyperactivated nucleotide-binding domain and leucine-rich repeat protein3 (NLRP3) inflammasomes with pyroptotic cell… read more here.
Keywords: tnt formation; transfer; dental pulp; bmscs ... See more keywords
TAT‐dextran–mediated mitochondrial transfer enhances recovery from models of reperfusion injury in cultured cardiomyocytes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15120
Abstract: Acute myocardial infarction is a leading cause of death among single organ diseases. Despite successful reperfusion therapy, ischaemia reperfusion injury (IRI) can induce oxidative stress (OS), cardiomyocyte apoptosis, autophagy and release of inflammatory cytokines, resulting… read more here.
Keywords: reperfusion injury; mitochondrial transfer; tat dextran; transfer ... See more keywords
Tunneling Nanotube-Mediated Mitochondrial Transfer Rescues Nucleus Pulposus Cells from Mitochondrial Dysfunction and Apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/3613319
Abstract: Stem cell-based therapy has been indicated to be beneficial for intervertebral disc regeneration. However, the underlying mechanisms have not been fully identified. The present study showed that bone marrow mesenchymal stem cells (BMSCs) donated mitochondria… read more here.
Keywords: pulposus cells; mitochondrial transfer; nucleus pulposus; mitochondrial dysfunction ... See more keywords