Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure
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DOI: 10.1038/ncomms14893
Abstract: Cholesterol is an important regulator of membrane protein function. However, the exact mechanisms involved in this process are still not fully understood. Here we study how the tertiary and quaternary structure of the mitochondrial translocator… read more here.
Keywords: protein; tspo; mitochondrial translocator; cholesterol ... See more keywords
Mitochondrial translocator protein deficiency exacerbates pathology in acute experimental ulcerative colitis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.896951
Abstract: In human patients and animal models of ulcerative colitis (UC), upregulation of the mitochondrial translocator protein (TSPO) in the colon is consistent with inflammation. Although the molecular function for TSPO remains unclear, it has been… read more here.
Keywords: translocator protein; tspo; mitochondrial translocator; pathology ... See more keywords