Mitochondrial Transplantation Augments the Reparative Capacity of Macrophages Following Myocardial Injury
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202506337
Abstract: The pathologically remodeled myocardial ischemic microenvironment, characterized by sustained hypoxia, metabolic insufficiency, and accumulation of inflammatory mediators, severely disrupts mitochondrial homeostasis. This dysfunction establishes a self‐perpetuating cycle that impairs the coordinated healing cascade and compromises… read more here.
Keywords: myocardial injury; following myocardial; transplantation augments; mitochondrial transplantation ... See more keywords
Alda-1 treatment promotes the therapeutic effect of mitochondrial transplantation for myocardial ischemia-reperfusion injury☆
Sign Up to like & getrecommendations! Published in 2021 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2020.12.024
Abstract: Mitochondrial damage is a critical driver in myocardial ischemia-reperfusion (I/R) injury and can be alleviated via the mitochondrial transplantation. The efficiency of mitochondrial transplantation is determined by mitochondrial vitality. Because aldehyde dehydrogenase 2 (ALDH2) has… read more here.
Keywords: mitochondrial transplantation; injury; transplantation; alda treatment ... See more keywords
Mitochondrial Transplantation for Organ Rescue.
Sign Up to like & getrecommendations! Published in 2022 at "Mitochondrion"
DOI: 10.1016/j.mito.2022.02.007
Abstract: Mitochondrial transplantation involves the replacement or augmentation of native mitochondria damaged, by ischemia, with viable, respiration-competent mitochondria isolated from non-ischemic tissue obtained from the patient's own body. The uptake and cellular functional integration of the… read more here.
Keywords: mitochondrial transplantation; transplantation; organ rescue; transplantation organ ... See more keywords
Mitochondrial Transplantation Therapy against Ifosfamide Induced Toxicity on Rat Renal Proximal Tubular Cells
Sign Up to like & getrecommendations! Published in 2022 at "Drug Research"
DOI: 10.1055/a-1967-2066
Abstract: Abstract Mitochondrial dysfunction is a basic mechanism leading to drug nephrotoxicity. Replacement of defective mitochondria with freshly isolated mitochondria is potentially a comprehensive tool to inhibit cytotoxicity induced by ifosfamide on renal proximal tubular cells… read more here.
Keywords: renal proximal; rptcs; rat; mitochondrial transplantation ... See more keywords
Mitochondrial Transplantation: A Unique Treatment Strategy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001247
Abstract: Mitochondrial transplantation refers to the process of introducing isolated mitochondria into a damaged area of the heart or other organs. In the past decade, this technique has been continuously updated as the fundamental research on… read more here.
Keywords: transplantation unique; mitochondrial transplantation; transplantation; treatment strategy ... See more keywords
Abstract Or107: Neuroprotective Effects of Delayed Mitochondrial Transplantation After Cardiac Arrest in Rats
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.or107
Abstract: Introduction: We previously demonstrated that mitochondrial transplantation (MTx) administered immediately after resuscitation improved 72-hour survival and neurological outcomes in a rat model of 10-minute asphyxial cardiac arrest (CA). However, the therapeutic efficacy of MTx when… read more here.
Keywords: mitochondrial transplantation; effects delayed; cardiac arrest; mtx ... See more keywords
Mitochondrial transplantation attenuates lipopolysaccharide-induced acute respiratory distress syndrome
Sign Up to like & getrecommendations! Published in 2024 at "BMC Pulmonary Medicine"
DOI: 10.1186/s12890-024-03304-2
Abstract: The mitochondria are essential organelles not only providing cellular energy in the form of ATP, but also regulating the inflammatory response and the cell death program. Mitochondrial dysfunction has been associated with various human diseases,… read more here.
Keywords: mitochondrial transplantation; respiratory distress; acute respiratory; distress syndrome ... See more keywords
Mitochondrial transplantation: a promising strategy for treating degenerative joint diseases
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-024-05752-0
Abstract: The prevalence of age-related degenerative joint diseases, particularly intervertebral disc degeneration and osteoarthritis, is increasing, thereby posing significant challenges for the elderly population. Mitochondrial dysfunction is a critical factor in the etiology and progression of… read more here.
Keywords: joint diseases; transplantation promising; mitochondrial transplantation; degenerative joint ... See more keywords
Mitochondrial transplantation attenuates alveolar epithelial cell dysfunction and reduces disruption of tight junction proteins to alleviate lung ischaemia-reperfusion injury
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-025-07360-y
Abstract: This study aims to investigate the therapeutic effect of exogenous mitochondrial transplantation (MT) on lung ischemia-reperfusion injury (LI/RI), and analyze the impact of MT on alveolar epithelial cell function and the ultrastructure of the alveolar… read more here.
Keywords: junction proteins; mitochondrial transplantation; epithelial cell; cell ... See more keywords
Current progress of mitochondrial transplantation that promotes neuronal regeneration
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DOI: 10.1186/s40035-019-0158-8
Abstract: BackgroundMitochondria are the major source of intracellular adenosine triphosphate (ATP) and play an essential role in a plethora of physiological functions, including the regulation of metabolism and the maintenance of cellular homeostasis. Mutations of mitochondrial… read more here.
Keywords: current progress; mitochondrial transplantation; regeneration; progress mitochondrial ... See more keywords
Mitochondrial transplantation—a novel therapeutic strategy for erectile dysfunction: a narrative review
Sign Up to like & getrecommendations! Published in 2025 at "Translational Andrology and Urology"
DOI: 10.21037/tau-2025-531
Abstract: Background and Objective Phosphodiesterase-5 inhibitors (PDE5i) remain the first-line treatment for erectile dysfunction (ED). However, nearly 30% of ED patients exhibit inadequate responses or intolerable side effects. Emerging evidence indicates that mitochondrial dysfunction, characterized by… read more here.
Keywords: mitochondrial transplantation; review; dysfunction; mitochondrial dysfunction ... See more keywords