Mitochondrial transport and metabolism of the major methyl donor and versatile cofactor S‐adenosylmethionine, and related diseases: A review†
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DOI: 10.1002/iub.2658
Abstract: S‐adenosyl‐L‐methionine (SAM) is a coenzyme and the most commonly used methyl‐group donor for the modification of metabolites, DNA, RNA and proteins. SAM biosynthesis and SAM regeneration from the methylation reaction product S‐adenosyl‐L‐homocysteine (SAH) take place… read more here.
Keywords: major methyl; sam; metabolism major; transport metabolism ... See more keywords
Nano-positioning and tubulin conformation contribute to axonal transport regulation of mitochondria along microtubules
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DOI: 10.1073/pnas.2203499119
Abstract: Significance Transport patterns of mitochondria are diverse with changes in velocity, directions, and pauses. Previous studies have mainly aimed at unraveling how motor proteins and their calcium dependency direct transport but fall short to elucidate… read more here.
Keywords: conformation; positioning tubulin; tubulin conformation; nano positioning ... See more keywords
Mutant TMEM230 induced neurodegeneration and impaired axonal mitochondrial transport.
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DOI: 10.1093/hmg/ddab128
Abstract: Parkinson's disease (PD) is a neurodegenerative disease with movement disorders including resting tremor, rigidity, bradykinesia, and postural instability. Recent studies have identified a new PD associated gene, TMEM230 (transmembrane protein 230). However, the pathological roles… read more here.
Keywords: protein; mutant tmem230; transport; tmem230 ... See more keywords