Mitochondrial tRNA mutations in 887 Chinese Subjects with Hearing Loss.
Sign Up to like & getrecommendations! Published in 2020 at "Mitochondrion"
DOI: 10.1016/j.mito.2020.03.005
Abstract: Mutations in the mitochondrial tRNAs have been reported to be the important cause of hearing loss. However, only a few cases have been identified thus far and the prevalence of mitochondrial tRNA mutations in hearing-impaired… read more here.
Keywords: hearing loss; chinese subjects; mitochondrial trna; trna mutations ... See more keywords
The mitochondrial tRNA conundrum
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/s41580-020-0220-5
Abstract: Lluís Ribas de Pouplana outlines the unanswered questions of mitochondrial transcription. read more here.
Keywords: biology; trna conundrum; mitochondrial trna;
Rapid shifts in mitochondrial tRNA import in a plant lineage with extensive mitochondrial tRNA gene loss.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology and evolution"
DOI: 10.1093/molbev/msab255
Abstract: In most eukaryotes, transfer RNAs (tRNAs) are one of the very few classes of genes remaining in the mitochondrial genome, but some mitochondria have lost these vestiges of their prokaryotic ancestry. Sequencing of mitogenomes from… read more here.
Keywords: trna; trna gene; gene loss; mitochondrial trna ... See more keywords
FARS2 deficiency in Drosophila reveals the developmental delay and seizure manifested by aberrant mitochondrial tRNA metabolism
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1187
Abstract: Abstract Mutations in genes encoding mitochondrial aminoacyl-tRNA synthetases are linked to diverse diseases. However, the precise mechanisms by which these mutations affect mitochondrial function and disease development are not fully understood. Here, we develop a… read more here.
Keywords: delay seizure; developmental delay; drosophila; mitochondrial trna ... See more keywords
Mitochondrial tRNA Mutation and Regulation of the Adiponectin Pathway in Maternally Inherited Hypertension in Chinese Han
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.623450
Abstract: Some essential hypertension (EH) patients show maternal inheritance, which is the mode of mitochondrial DNA inheritance. This study examines the mechanisms by which mitochondrial mutations cause EH characterized by maternal inheritance. The study enrolled 115… read more here.
Keywords: maternally inherited; mitochondrial trna; hypertension; trna 15910 ... See more keywords
Mitochondrial tRNA Mutations Associated With Essential Hypertension: From Molecular Genetics to Function
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.634137
Abstract: Essential hypertension (EH) is one of the most common cardiovascular diseases worldwide, entailing a high level of morbidity. EH is a multifactorial disease influenced by both genetic and environmental factors, including mitochondrial DNA (mtDNA) genotype.… read more here.
Keywords: genetics; mitochondrial trna; mutations associated; hypertension ... See more keywords
Novel and heteroplasmic mutations in mitochondrial tRNA genes in Brugada syndrome.
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DOI: 10.5603/cj.a2017.0104
Abstract: BACKGROUND Brugada syndrome (BrS) is a rare cardiac arrhythmia characterized by sudden death associated with electrocardiogram patterns characterized by incomplete right bundle-branch block and ST-segment elevations in the anterior precordial leads. This syndrome predominantly is… read more here.
Keywords: brs; novel heteroplasmic; brugada syndrome; mitochondrial trna ... See more keywords
Mutational Screening for Mitochondrial tRNA Mutations in 150 Children with High Myopia
Sign Up to like & getrecommendations! Published in 2021 at "Iranian Journal of Pediatrics"
DOI: 10.5812/ijp.115288
Abstract: Background: Myopia is a very common eye disease with an unknown etiology. Increasing evidence shows that mitochondrial dysfunction plays an active role in the pathogenesis and progression of this disease. Objectives: The purpose of this… read more here.
Keywords: screening mitochondrial; high myopia; 150 children; mitochondrial trna ... See more keywords