Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.10.018
Abstract: Mitochondria contain a specific translation machinery for the synthesis of mitochondria-encoded respiratory chain components. Mitochondrial tRNAs (mt-tRNAs) are also generated from the mitochondrial DNA and, similar to their cytoplasmic counterparts, are post-transcriptionally modified. Here, we… read more here.
Keywords: respiratory chain; mettl8 mediated; mettl8; mitochondrial trnas ... See more keywords
Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-14725-y
Abstract: Metazoan complexity and life-style depend on the bioenergetic potential of mitochondria. However, higher aerobic activity and genetic drift impose strong mutation pressure and risk of irreversible fitness decline in mitochondrial (mt)DNA-encoded genes. Bilaterian mitochondria-encoded tRNA… read more here.
Keywords: mitochondrial trnas; relaxed sequence; sequence constraints; mutational freedom ... See more keywords
Complete chemical structures of human mitochondrial tRNAs
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18068-6
Abstract: Mitochondria generate most cellular energy via oxidative phosphorylation. Twenty-two species of mitochondrial (mt-)tRNAs encoded in mtDNA translate essential subunits of the respiratory chain complexes. mt-tRNAs contain post-transcriptional modifications introduced by nuclear-encoded tRNA-modifying enzymes. They are… read more here.
Keywords: mitochondrial trnas; human mitochondrial; trna modifications; chemical structures ... See more keywords
Mammalian NSUN2 introduces 5-methylcytidines into mitochondrial tRNAs
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz575
Abstract: Abstract Post-transcriptional modifications in mitochondrial tRNAs (mt-tRNAs) play critical roles in mitochondrial protein synthesis, which produces respiratory chain complexes. In this study, we took advantage of mass spectrometric analysis to map 5-methylcytidine (m5C) at positions… read more here.
Keywords: microscopy; mitochondrial trnas; nsun2 introduces; methylcytidines mitochondrial ... See more keywords
Arm-less mitochondrial tRNAs conserved for over 30 millions of years in spiders
Sign Up to like & getrecommendations! Published in 2019 at "BMC Genomics"
DOI: 10.1186/s12864-019-6026-1
Abstract: BackgroundIn recent years, Next Generation Sequencing (NGS) has accelerated the generation of full mitogenomes, providing abundant material for studying different aspects of molecular evolution. Some mitogenomes have been observed to harbor atypical sequences with bizarre… read more here.
Keywords: secondary structures; mitochondrial trnas; trnas; arm less ... See more keywords
Maturation of selected human mitochondrial tRNAs requires deadenylation
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.27596
Abstract: Human mitochondria contain a genome (mtDNA) that encodes essential subunits of the oxidative phosphorylation system. Expression of mtDNA entails multi-step maturation of precursor RNA. In other systems, the RNA life cycle involves surveillance mechanisms, however,… read more here.
Keywords: selected human; mitochondrial trnas; human mitochondrial; human mitochondria ... See more keywords