Mitochondrial uncoupling proteins UCP4 and UCP5 from the Pacific white shrimp Litopenaeus vannamei
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-019-09789-5
Abstract: Mitochondrial uncoupling proteins (UCP) transport protons from the intermembrane space to the mitochondrial matrix uncoupling oxidative phosphorylation. In mammals, these proteins have been implicated in several cellular functions ranging from thermoregulation to antioxidant defense. In… read more here.
Keywords: litopenaeus vannamei; shrimp litopenaeus; white shrimp; mitochondrial uncoupling ... See more keywords
Preconditioning of bull semen with sub-lethal oxidative stress before cryopreservation: Possible mechanism of mitochondrial uncoupling protein 2.
Sign Up to like & getrecommendations! Published in 2021 at "Cryobiology"
DOI: 10.1016/j.cryobiol.2021.11.001
Abstract: Preconditioning of sperm using sub-lethal oxidative stress before cryopreservation is an innovative approach that can improve sperm cryo-survival. Mitochondrial uncoupling proteins (UCPs) are critical in reducing ROS level during stress conditions. The aim of the… read more here.
Keywords: lethal oxidative; mitochondrial uncoupling; sub lethal; stress ... See more keywords
Mitochondrial uncoupling and longevity – A role for mitokines?
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2019.110796
Abstract: Aging has been viewed both as a random process due to accumulation of molecular and cellular damage over time and as a programmed process linked to cellular pathway important for growth and maturation. These views… read more here.
Keywords: uncoupling longevity; response; mitochondrial uncoupling; longevity role ... See more keywords
Specific Interaction of the Human Mitochondrial Uncoupling Protein 1 with Free Long-Chain Fatty Acid.
Sign Up to like & getrecommendations! Published in 2017 at "Structure"
DOI: 10.1016/j.str.2017.07.005
Abstract: The mitochondrial uncoupling protein 1 (UCP1) generates heat by causing proton leak across the mitochondrial inner membrane that requires fatty acid (FA). The mechanism by which UCP1 uses FA to conduct proton remains unsolved, and… read more here.
Keywords: chain; mitochondrial uncoupling; specific interaction; fatty acid ... See more keywords
Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14095
Abstract: Ischaemic heart disease limits oxygen and metabolic substrate availability to the heart, resulting in tissue death. Here, we demonstrate that the AMP-activated protein kinase (AMPK)-related protein Snf1-related kinase (SNRK) decreases cardiac metabolic substrate usage and… read more here.
Keywords: mitochondrial uncoupling; snf1 related; mitochondrial efficiency; related kinase ... See more keywords
Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05805-1
Abstract: There are considerable challenges in directly targeting the mutant p53 protein, given the large heterogeneity of p53 mutations in the clinic. An alternative approach is to exploit the altered fitness of cells imposed by loss-of-wild-type… read more here.
Keywords: mitochondrial uncoupling; type p53; mutant p53; p53 deficient ... See more keywords
Berberine chloride (dual topoisomerase I and II inhibitor) modulate mitochondrial uncoupling protein (UCP1) in molecular docking and dynamic with in-vitro cytotoxic and mitochondrial ATP production
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2021.2024255
Abstract: Abstract Obesity initiates numerous diseases like cardiovascular, metabolic, and type 2 diabetes, and obesity is a vital cause of death worldwide. Plants are necessary to the source of life. Several drug compounds isolated from plants… read more here.
Keywords: berberine chloride; mitochondrial uncoupling; berberine; chloride dual ... See more keywords
Mitochondrial uncoupling induces epigenome remodeling and promotes differentiation in neuroblastoma.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-1029
Abstract: The Warburg effect is the major metabolic hallmark of cancer. According to Warburg himself, the consequence of the Warburg effect is cell dedifferentiation. Therefore, reversing the Warburg effect might be an approach to restore cell… read more here.
Keywords: differentiation neuroblastoma; warburg effect; mitochondrial uncoupling; nen treatment ... See more keywords
Fifty Years of Research on Protonophores: Mitochondrial Uncoupling As a Basis for Therapeutic Action
Sign Up to like & getrecommendations! Published in 2022 at "Acta Naturae"
DOI: 10.32607/actanaturae.11610
Abstract: Protonophores are compounds capable of electrogenic transport of protons across membranes. Protonophores have been intensively studied over the past 50 years owing to their ability to uncouple oxidation and phosphorylation in mitochondria and chloroplasts. The… read more here.
Keywords: protonophores mitochondrial; research protonophores; years research; mitochondrial uncoupling ... See more keywords