HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12863
Abstract: The mitochondrial unfolded protein response (UPRmt) is characterized by the transcriptional induction of mitochondrial chaperone and protease genes in response to impaired mitochondrial proteostasis and is regulated by ATF5 and CHOP in mammalian cells. However,… read more here.
Keywords: response; induction mitochondrial; hsf1; mitochondrial unfolded ... See more keywords
Knockdown of TMEM160 leads to an increase in reactive oxygen species generation and the induction of the mitochondrial unfolded protein response
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DOI: 10.1002/2211-5463.13496
Abstract: Transmembrane protein 160 (TMEM160) was recently reported to be localized to the mitochondrial inner membrane, but mitochondrial function was noted to be unaffected by loss of TMEM160. In contrast to these previously published findings, we… read more here.
Keywords: tmem160 depletion; depletion; generation; mitochondrial unfolded ... See more keywords
MicroRNA‐382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27401
Abstract: Proper mitochondrial function plays a central role in cellular metabolism. Various diseases as well as aging are associated with diminished mitochondrial function. Previously, we identified 19 miRNAs putatively involved in the regulation of mitochondrial metabolism… read more here.
Keywords: imbalance; unfolded protein; muscle; protein response ... See more keywords
Honokiol improves cognitive impairment in APP/PS1 mice through activating mitophagy and mitochondrial unfolded protein response.
Sign Up to like & getrecommendations! Published in 2021 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2021.109741
Abstract: Activated mitophagy and mitochondrial unfolded protein response (UPRmt) has been reported to protect against mitochondrial dysfunction, which is closely related to the onset of Alzheimer's disease (AD). Honokiol (HKL, C18H18O2) is a kind of natural… read more here.
Keywords: hkl; mitophagy mitochondrial; ps1 mice; mitochondrial unfolded ... See more keywords
Mitochondrial Unfolded Protein Response (UPRmt) Activation in Cardiac Diseases: Opportunities and Challenges.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2019.05.066
Abstract: As reported by Smyrnias et al. [(1)][1], pre-induction of mitochondrial unfolded protein response (UPRmt) using nicotinamide riboside is sufficient to prevent cardiac dysfunction induced by chronic hemodynamic overload in rodents. These findings open up a new… read more here.
Keywords: response uprmt; unfolded protein; protein response; mitochondrial unfolded ... See more keywords
Mitochondrial dysfunction, aging, and the mitochondrial unfolded protein response in Caenorhabditis elegans.
Sign Up to like & getrecommendations! Published in 2022 at "Genetics"
DOI: 10.1093/genetics/iyac160
Abstract: We review the findings that establish that perturbations of various aspects of mitochondrial function, including oxidative phosphorylation, can promote lifespan extension, with different types of perturbations acting sometimes independently and additively on extending lifespan. We… read more here.
Keywords: mitochondrial dysfunction; unfolded protein; mitochondrial unfolded; protein response ... See more keywords
The Mitochondrial Unfolded Protein Response: A Novel Protective Pathway Targeting Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/6430342
Abstract: Mitochondrial protein homeostasis in cardiomyocyte injury determines not only the normal operation of mitochondrial function but also the fate of mitochondria in cardiomyocytes. Studies of mitochondrial protein homeostasis have become an integral part of cardiovascular… read more here.
Keywords: unfolded protein; protein homeostasis; mitochondrial protein; mitochondrial unfolded ... See more keywords
Abstract 16554: Sphingosine-1-Phosphate Activates the Mitochondrial Unfolded Protein Response in the Pulmonary Vasculature
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.16554
Abstract: Introduction: Aberrant activation of pathways that promote pulmonary arterial smooth muscle (PASMC) and endothelial cell (PAEC) proliferation causes vascular remodeling and increased vascular resistance that leads to the deadly disease Pulmonary Arterial Hypertension (PAH). Sphingosine-1-phosphate… read more here.
Keywords: activation; activation upr; sphingosine phosphate; proliferation ... See more keywords
The Mitochondrial Unfolded Protein Response: Role in Cellular Homeostasis and Disease.
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DOI: 10.2174/1566524018666180308110130
Abstract: Mitochondria are the sole semiautonomous organelles of the human cell and play a very important role in not only energy production but also in apoptosis, metabolism and cell signaling. They are also known to be… read more here.
Keywords: unfolded protein; protein response; disease; mitochondrial unfolded ... See more keywords
Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors
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DOI: 10.26508/lsa.202101182
Abstract: This work highlights the importance of the mitochondrial unfolded protein response in allowing organisms to survive external stressors through up-regulation of other stress response pathways. read more here.
Keywords: response; unfolded protein; protein response; activation mitochondrial ... See more keywords
Trends in mitochondrial unfolded protein response research from 2004 to 2022: A bibliometric analysis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1146963
Abstract: The mitochondrial unfolded protein response (UPRmt) is a stress response pathway that regulates the expression of mitochondrial chaperones, proteases, and other proteins involved in protein folding and degradation, thereby ensuring proper mitochondrial function. In addition… read more here.
Keywords: unfolded protein; mitochondrial unfolded; protein response; 2004 2022 ... See more keywords