Articles with "mitochondrial upr" as a keyword



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Folding the Mitochondrial UPR into the Integrated Stress Response.

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Published in 2020 at "Trends in cell biology"

DOI: 10.1016/j.tcb.2020.03.001

Abstract: Eukaryotic cells must accurately monitor the integrity of the mitochondrial network to overcome environmental insults and respond to physiological cues. The mitochondrial unfolded protein response (UPRmt) is a mitochondrial-to-nuclear signaling pathway that maintains mitochondrial proteostasis,… read more here.

Keywords: response; mitochondrial upr; integrated stress; stress response ... See more keywords
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Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans

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Published in 2019 at "Journal of Cell Science"

DOI: 10.1242/jcs.223891

Abstract: ABSTRACT The Fe(II) and 2-oxoglutarate-dependent oxygenase Alkb homologue 1 (Alkbh1) has been shown to act on a wide range of substrates, like DNA, tRNA and histones. Thereby different enzymatic activities have been identified including, among… read more here.

Keywords: alkbh1; mitochondrial upr; knockdown induces; microscopy ... See more keywords