Mitochondrion‐Targeting Identification of a Fluorescent Apoptosis‐Triggering Molecule by Mass Spectrometry Elucidates Drug Tracking
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201800598
Abstract: The real‐time tracking of localization and dynamics of small molecules in organelles helps to understand their function and identification of their potential targets at subcellular resolution. To identify the mitochondrion‐targeting effects of small molecules (NA‐17… read more here.
Keywords: mitochondrion; identification; mitochondrion targeting; mass spectrometry ... See more keywords
Differently Tagged Probes for Protein Profiling of Mitochondria
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201800735
Abstract: The mitochondrion is one of the most important organelles in the eukaryotic cell. Characterization of the mitochondrial proteome is a prerequisite for understanding its cellular functions at the molecular level. Here we report a proteomics… read more here.
Keywords: probes protein; tagged probes; protein profiling; mitochondrion ... See more keywords
Pervasive within-Mitochondrion Single-Nucleotide Variant Heteroplasmy as Revealed by Single-Mitochondrion Sequencing.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.11.031
Abstract: A number of mitochondrial diseases arise from single-nucleotide variant (SNV) accumulation in multiple mitochondria. Here, we present a method for identification of variants present at the single-mitochondrion level in individual mouse and human neuronal cells,… read more here.
Keywords: single mitochondrion; single nucleotide; revealed single; nucleotide variant ... See more keywords
Reinventing an Organelle: The Reduced Mitochondrion in Parasitic Protists.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in parasitology"
DOI: 10.1016/j.pt.2018.08.008
Abstract: Mitochondria originated from the endosymbiotic event commencing from the engulfment of an ancestral α-proteobacterium by the first eukaryotic ancestor. Establishment of niches has led to various adaptations among eukaryotes. In anaerobic parasitic protists, the mitochondria… read more here.
Keywords: reduced mitochondrion; parasitic protists; mitochondrion parasitic; mitochondrion ... See more keywords
Mitochondrion-Targeted Triphenylphosphonium-Based Kresoxim-Methyl Analogues: Synthesis, Fungicidal Activity, and Action Mechanism Approach.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c05071
Abstract: β-Methoxyacrylate fungicides as complex III Qo site inhibitors play a crucial role in the control of crop diseases. In this study, the triphenylphosphonium (TPP)-driven mitochondrion-targeting strategy was used to modify the kresoxim-methyl scaffold at the… read more here.
Keywords: mitochondrion; kresoxim methyl; activity; methyl analogues ... See more keywords
Construction of a TICT-AIE-Integrated Unimolecular Platform for Imaging Lipid Droplet-Mitochondrion Interactions in Live Cells and In Vivo.
Sign Up to like & getrecommendations! Published in 2022 at "ACS sensors"
DOI: 10.1021/acssensors.2c01361
Abstract: Inter-organelle interactions play a vital role in diverse biological processes. Thus, chemical tools are highly desirable for understanding the spatiotemporal dynamic interplay among organelles in live cells and in vivo. However, designing such tools is… read more here.
Keywords: mitochondrion; tict aie; live cells; mitochondrion interactions ... See more keywords
Evidence of mitochondrial DNA in the chloroplast genome of Convallaria keiskei and its subsequent evolution in the Asparagales
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41377-w
Abstract: DNA transfer between internal organelles such as the nucleus, mitochondrion, and plastid is a well-known phenomenon in plant evolution, and DNA transfer from the plastid and mitochondrion to the nucleus, from the plastid to the… read more here.
Keywords: convallaria keiskei; dna; transfer; chloroplast genome ... See more keywords
Mitochondrion-targeted selenium nanoparticles enhance reactive oxygen species-mediated cell death.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/c9nr09039h
Abstract: Selenium nanoparticles (SeNPs) can induce reactive oxygen species (ROS)-mediated cell death when accumulated in cancer cells, while rendering anti-oxidation and cancer prevention in healthy tissues at low doses. Although they are promising anticancer agents with… read more here.
Keywords: reactive oxygen; oxygen species; mediated cell; cancer ... See more keywords
Identification of the metabolic remodeling profile in the early-stage of myocardial ischemia and the contributory role of mitochondrion
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2068882
Abstract: ABSTRACT Cardiac remodeling is the primary pathological feature of chronic heart failure. Prompt inhibition of remodeling in acute coronary syndrome has been a standard procedure, but the morbidity and mortality are still high. Exploring the… read more here.
Keywords: mitochondrion; ischemia; early ischemia; metabolic remodeling ... See more keywords
The Pseudomonas aeruginosa Type III Secretion System Exoenzyme Effector ExoU Induces Mitochondrial Damage in a Murine Bone Marrow-Derived Macrophage Infection Model
Sign Up to like & getrecommendations! Published in 2022 at "Infection and Immunity"
DOI: 10.1128/iai.00470-21
Abstract: Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen that causes nosocomial pneumonia, urinary tract infections, and bacteremia. A hallmark of P. aeruginosa pathogenesis is disruption of host cell function by the type III secretion system (T3SS)… read more here.
Keywords: mitochondrion; type iii; pseudomonas aeruginosa; iii secretion ... See more keywords
Modeling the Life Cycle of the Intramitochondrial Bacterium “Candidatus Midichloria mitochondrii” Using Electron Microscopy Data
Sign Up to like & getrecommendations! Published in 2021 at "mBio"
DOI: 10.1128/mbio.00574-21
Abstract: Our results suggest that Midichloria mitochondrii, the intramitochondrial bacterium, does not invade mitochondria like predatory bacteria do but instead moves from mitochondrion to mitochondrion within the oocytes of Ixodes ricinus. A better understanding of the… read more here.
Keywords: microscopy; mitochondrion; bacterium; midichloria mitochondrii ... See more keywords