Mitochondrion‐Targeted Type I Photodynamic Therapy for Agonist Independent cGAS‐STING Activation
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Materials"
DOI: 10.1002/adma.202418894
Abstract: CGAS‐STING agonists generally lead to hyperimmunity and systemic toxicity, hindering their immunotherapeutic outcomes. Herein, a mitochondrion‐targeted nanoagonist (termed HABH) containing boron dipyrromethene (BODIPY)‐derived type I photosensitizer (BDP) and Au nanoparticle‐engineered hollow mesoporous silica (HMSN/AuNPs) has… read more here.
Keywords: cgas; agonist independent; mitochondrion targeted; independent cgas ... See more keywords
Mitochondrion-Targeted Triphenylphosphonium-Based Kresoxim-Methyl Analogues: Synthesis, Fungicidal Activity, and Action Mechanism Approach.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c05071
Abstract: β-Methoxyacrylate fungicides as complex III Qo site inhibitors play a crucial role in the control of crop diseases. In this study, the triphenylphosphonium (TPP)-driven mitochondrion-targeting strategy was used to modify the kresoxim-methyl scaffold at the… read more here.
Keywords: mitochondrion; kresoxim methyl; activity; methyl analogues ... See more keywords
Chronic administration of mitochondrion-targeted peptide SS-31 prevents atherosclerotic development in ApoE knockout mice fed Western diet
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0185688
Abstract: Background Oxidative stress and inflammatory factors are deeply involved in progression of atherosclerosis. Mitochondrion-targeted peptide SS-31, selectively targeting to mitochondrial inner membrane reacting with cardiolipin, has been reported to inhibit ROS generation and mitigate inflammation.… read more here.
Keywords: administration; fed western; mitochondrion targeted; western diet ... See more keywords
The Mitochondrion-targeted Antioxidants in Kidney Disease.
Sign Up to like & getrecommendations! Published in 2020 at "Current medicinal chemistry"
DOI: 10.2174/0929867327666201020151124
Abstract: Mitochondria are potent source of cellular reactive oxygen species (ROS) and are vulnerable to oxidative damage. Mitochondria dysfunction could result in adenosine triphosphate (ATP) decrease and cell death. The kidney is an ATPconsuming organ, and… read more here.
Keywords: mitochondrion targeted; antioxidants kidney; chemistry; disease ... See more keywords