Mitochondrion‐Targeting Identification of a Fluorescent Apoptosis‐Triggering Molecule by Mass Spectrometry Elucidates Drug Tracking
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DOI: 10.1002/cbic.201800598
Abstract: The real‐time tracking of localization and dynamics of small molecules in organelles helps to understand their function and identification of their potential targets at subcellular resolution. To identify the mitochondrion‐targeting effects of small molecules (NA‐17… read more here.
Keywords: mitochondrion; identification; mitochondrion targeting; mass spectrometry ... See more keywords
Differently Tagged Probes for Protein Profiling of Mitochondria
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DOI: 10.1002/cbic.201800735
Abstract: The mitochondrion is one of the most important organelles in the eukaryotic cell. Characterization of the mitochondrial proteome is a prerequisite for understanding its cellular functions at the molecular level. Here we report a proteomics… read more here.
Keywords: probes protein; tagged probes; protein profiling; mitochondrion ... See more keywords
Impact of Mitochondrion-Targeting Group on the Reactivity and Cytostatic Pathway of Platinum(IV) Complexes.
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DOI: 10.1021/acs.inorgchem.8b01707
Abstract: Platinum(IV) complexes are prodrugs of cisplatin with multiple potential advantages over platinum(II) drugs. Mitochondria play pivotal roles in producing energy and inducing death of cancer cells. Two platinum(IV) complexes, namely, c,c,t-[Pt(NH3)2Cl2(OH)(OCOCH2CH2CH2CH2PPh3)]Br and c,c,t-[Pt(NH3)2Cl2(OCOCH2CH2CH2CH2PPh3)2]Br2, were designed… read more here.
Keywords: platinum; targeting group; reactivity; platinum complexes ... See more keywords