Conditional deletion of myeloid-specific mitofusin 2 but not mitofusin 1 promotes kidney fibrosis.
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DOI: 10.1016/j.kint.2022.01.030
Abstract: Macrophages exert critical functions during kidney injury, inflammation, and tissue repair or fibrosis. Mitochondrial structural and functional aberrations due to an imbalance in mitochondrial fusion/fission processes are implicated in the pathogenesis of chronic kidney disease.… read more here.
Keywords: mfn2; kidney fibrosis; mitofusin; macrophage ... See more keywords
Expression of mitofusin 2 in human sperm and its relationship to sperm motility and cryoprotective potentials
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DOI: 10.1177/1535370218790919
Abstract: Mitofusin 2 is a kind of mitochondria membrane protein that has been implicated in maintenance of mitochondrial morphology and function. However, the expression and function of mitofusin 2 in human sperm are not well described… read more here.
Keywords: mitofusin; human sperm; motility cryoprotective; cryoprotective potentials ... See more keywords
Mitofusin-2 Expression Is Implicated in Cervical Cancer Pathogenesis
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DOI: 10.21873/anticanres.12610
Abstract: Background/Aim: It remains unclear whether mitofusin-2 (MFN2) functions as a tumour suppressor or oncogene in cancer progression. In this study we, therefore, aimed to investigate the effect of MFN2 on the pathogenesis of cervical cancer.… read more here.
Keywords: mitofusin; cervical cancer; cancer pathogenesis; expression ... See more keywords
A dominant negative mitofusin causes mitochondrial perinuclear clusters because of aberrant tethering
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DOI: 10.26508/lsa.202101305
Abstract: Our analysis of a CMT2A-associated mitofusin variant reveals that aberrant mitochondrial tethering results in perinuclear clusters and that conformational dynamics in Hinge 2 are required to progress from membrane tethering to membrane fusion. In vertebrates,… read more here.
Keywords: mitofusin; fusion; membrane fusion; mitochondrial perinuclear ... See more keywords