Ocular Toxicity of Mitogen-Activated Protein Kinase Inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2016.4213
Abstract: Ocular Toxicity of Mitogen-Activated Protein Kinase Inhibitors The Oxford Eye Hospital and the Oxford Experimental Cancer Centre collaborate in monitoring patients in a number of early-phase clinical trials. In this study, we report the ocular… read more here.
Keywords: kinase inhibitors; protein kinase; mitogen activated; activated protein ... See more keywords
Mg–Al and Zn–Al Layered Double Hydroxides Promote Dynamic Expression of Marker Genes in Osteogenic Differentiation by Modulating Mitogen‐Activated Protein Kinases
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201700693
Abstract: The effect of LDH samples comprised of chloride anions intercalated between positive layers of magnesium/aluminum (Mg-Al LDH) or zinc/aluminum (Zn-Al LDH) chemical composition on pre-osteoblast performance is investigated. Non-cytotoxic concentrations of both LDHs modulated pre-osteoblast… read more here.
Keywords: layered double; marker genes; activated protein; differentiation ... See more keywords
Perineural invasion is related to p38 mitogen‐activated protein kinase pathway activation and promotes tumor growth and chemoresistance in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28457
Abstract: Metastasis is a key component of cancer progression and is strongly associated with poor prognosis. Perineural invasion is thought to be related to pain, tumor recurrence, and other conditions. However, the exact molecular mechanism is… read more here.
Keywords: perineural invasion; pancreatic cancer; p38 mitogen; cancer ... See more keywords
Mapping p38α mitogen‐activated protein kinase signaling by proximity‐dependent labeling
Sign Up to like & getrecommendations! Published in 2020 at "Protein Science"
DOI: 10.1002/pro.3854
Abstract: Mitogen‐activated protein (MAP) kinase signaling is central to multiple cellular responses and processes. MAP kinase p38α is the best characterized member of the p38 MAP kinase family. Upstream factors and downstream targets of p38α have… read more here.
Keywords: kinase; activated protein; p38; map kinase ... See more keywords
Static magnetic fields enhance dental pulp stem cell proliferation by activating the p38 mitogen‐activated protein kinase pathway as its putative mechanism
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2333
Abstract: Dental pulp stem cells (DPSCs) can be a potential stem cell resource for clinical cell therapy and tissue engineering. However, obtaining a sufficient number of DPSCs for repairing defects is still an issue in clinical… read more here.
Keywords: activated protein; p38 mitogen; proliferation; cell ... See more keywords
Thymoquinone induces apoptosis in temozolomide‐resistant glioblastoma cells via the p38 mitogen‐activated protein kinase signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23664
Abstract: Temozolomide (TMZ) can cross the blood‐brain barrier (BBB) and deliver methyl groups to the purine (guanine) bases of DNA, leading to mispairing during DNA replication and subsequent cell death. However, increased expression of the repair… read more here.
Keywords: mitogen activated; protein kinase; activated protein; p38 mitogen ... See more keywords
Identification of novel MEK1 inhibitors by pharmacophore and docking based virtual screening
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1788-y
Abstract: AbstractMitogen-activated protein kinase/mitogen-activated protein kinase kinase1 plays a key role in the Ras/Raf/MEK/ERK signaling pathway associated with cell growth, differentiation and development. In an effort to identify novel mitogen-activated protein kinase kinase1 inhibitors, an efficient… read more here.
Keywords: virtual screening; activated protein; kinase kinase1; protein kinase ... See more keywords
OsVQ1 links rice immunity and flowering via interaction with a mitogen-activated protein kinase OsMPK6.
Sign Up to like & getrecommendations! Published in 2021 at "Plant cell reports"
DOI: 10.1007/s00299-021-02766-6
Abstract: KEY MESSAGE Knocking out OsVQ1 in rice released OsMPK6 for activation and in turn promoted H2O2 accumulation, which repressed the expression of flowering-promoting genes, thus delaying rice flowering but enhancing disease resistance. The valine-glutamine (VQ)… read more here.
Keywords: immunity; rice; flowering; activated protein ... See more keywords
Mitogen activated protein kinase 6 and MAP kinase phosphatase 1 are involved in the response of Arabidopsis roots to l-glutamate
Sign Up to like & getrecommendations! Published in 2018 at "Plant Molecular Biology"
DOI: 10.1007/s11103-018-0699-8
Abstract: Key messageThe function and components of l-glutamate signaling pathways in plants have just begun to be elucidated. Here, using a combination of genetic and biochemical strategies, we demonstrated that a MAPK module is involved in… read more here.
Keywords: response; kinase; root; activated protein ... See more keywords
Clinical Pharmacokinetics and Pharmacodynamics of Selumetinib
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DOI: 10.1007/s40262-020-00967-y
Abstract: Selumetinib, a highly specific mitogen-activated protein kinase 1/2 inhibitor, is approved for children older than 2 years of age with neurofibromatosis 1 who have inoperable plexiform neurofibromas. By selectively binding to mitogen-activated protein kinase 1/2… read more here.
Keywords: selumetinib; clinical pharmacokinetics; activated protein; protein kinase ... See more keywords
Mitogen-activated protein kinase (MAPK) signalling corresponds with distinct behavioural profiles in a rat model of maternal immune activation
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2020.112876
Abstract: Dysfunction within the mitogen-activated protein kinase (MAPK) cascade has been recognised as a pathological feature of schizophrenia, however the possible mechanistic connection to the disease phenotype remains unexplored. Using the maternal immune activation (MIA) rat… read more here.
Keywords: maternal immune; protein kinase; activated protein; kinase mapk ... See more keywords