Iron–sulfur cluster redox chemistry and dimer dissociation in the outer mitochondrial membrane protein, mitoNEET
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biological Inorganic Chemistry"
DOI: 10.1007/s00775-024-02093-7
Abstract: The outer mitochondrial membrane protein known as mitoNEET was discovered when it was labeled by a photoaffinity derivative of the anti-diabetes medication, pioglitazone. The biological role for mitoNEET and its specific mechanism for achieving this… read more here.
Keywords: chemistry; iron sulfur; protein; membrane ... See more keywords
Bioenergetic restoration and neuroprotection after therapeutic targeting of mitoNEET: New mechanism of pioglitazone following traumatic brain injury
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113243
Abstract: Mitochondrial dysfunction is a pivotal event in many neurodegenerative disease states including traumatic brain injury (TBI) and spinal cord injury (SCI). One possible mechanism driving mitochondrial dysfunction is glutamate excitotoxicity leading to Ca2+-overload in neuronal… read more here.
Keywords: mitoneet; mechanism; pioglitazone; dysfunction ... See more keywords
Controlled Protonation of [2Fe-2S] Leading to MitoNEET Analogues and Concurrent Cluster Modification.
Sign Up to like & getrecommendations! Published in 2021 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.1c02622
Abstract: MitoNEET, a key regulatory protein in mitochondrial energy metabolism, exhibits a uniquely ligated [2Fe-2S] cluster with one histidine and three cysteines. This unique cluster has been postulated to sense the redox environment and release Fe-S… read more here.
Keywords: mitoneet; chemistry; fe2s2 sph; cluster ... See more keywords
Anamorsin/Ndor1 Complex Reduces [2Fe-2S]-MitoNEET via a Transient Protein-Protein Interaction.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b05003
Abstract: Human mitoNEET is a homodimeric protein anchored to the outer mitochondrial membrane and has a C-terminal [2Fe-2S] binding domain located in the cytosol. Recently, human mitoNEET has been shown to be implicated in Fe/S cluster… read more here.
Keywords: protein; mitoneet; 2fe mitoneet; transfer ... See more keywords
Redox-dependent gating of VDAC by mitoNEET
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1908271116
Abstract: Significance This work demonstrates that the outer mitochondrial-anchored [2Fe-2S] mitoNEET is able to bind within the central cavity of the voltage-dependent anion channel (VDAC) and regulate its gating in a redox-dependent manner. These findings have… read more here.
Keywords: mitoneet; mitoneet redox; vdac; outer mitochondrial ... See more keywords
Abstract Tu123: Redox Biology of the Mitochondrial Protein mitoNEET and Ascorbate
Sign Up to like & getrecommendations! Published in 2024 at "Circulation Research"
DOI: 10.1161/res.135.suppl_1.tu123
Abstract: Background: It has been proposed that mitoNEET is an Fe-S transfer/repair enzyme, playing a role under conditions of oxidative stress. mitoNEET protects mitochondria against oxidative stress in cardiomyocytes. Loss of mitoNEET is linked with age-related… read more here.
Keywords: redox biology; mitoneet ascorbate; biology; mitoneet ... See more keywords
Loss of the mitochondrial protein mitoNEET in mice is associated with cognitive impairments and increased neuroinflammation
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Alzheimer's Disease"
DOI: 10.1177/13872877241302456
Abstract: Background Mitochondrial dysfunction is implicated in several neurodegenerative diseases associated with memory and cognitive deficits, including Alzheimer's disease. Changes in bioenergetic function results in reactive oxygen species, oxidative damage and consequently neuroinflammation, which contributes to… read more here.
Keywords: protein mitoneet; mitoneet mice; loss; mice associated ... See more keywords
Multiple Poses and Thermodynamics of Ligands Targeting Protein Surfaces: The Case of Furosemide Binding to mitoNEET in Aqueous Solution
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.886568
Abstract: Human NEET proteins, such as NAF-1 and mitoNEET, are homodimeric, redox iron-sulfur proteins characterized by triple cysteine and one histidine-coordinated [2Fe-2S] cluster. They exist in an oxidized and reduced state. Abnormal release of the cluster… read more here.
Keywords: mitoneet; structure; thermodynamics; solution ... See more keywords