Engineered Extracellular Vesicles with SHP2 High Expression Promote Mitophagy for Alzheimer's Disease Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202207107
Abstract: Mitochondrial dysfunction is a fundamental pathological feature of Alzheimer's disease (AD). However, toxicity and poor brain enrichment of existing mitophagy inducers limit their further applications. In this study, a platform for AD therapy is developed… read more here.
Keywords: extracellular vesicles; alzheimer disease; high expression; mitophagy ... See more keywords
MCU Upregulation Overactivates Mitophagy by Promoting VDAC1 Dimerization and Ubiquitination in the Hepatotoxicity of Cadmium
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202203869
Abstract: Cadmium (Cd) is a high‐risk pathogenic toxin for hepatic diseases. Excessive mitophagy is a hallmark in Cd‐induced hepatotoxicity. However, the underlying mechanism remains obscure. Mitochondrial calcium uniporter (MCU) is a key regulator for mitochondrial and… read more here.
Keywords: mcu; cadmium; mitophagy; hepatotoxicity ... See more keywords
Pyrimidine‐Based Fluorescent Probe for Monitoring Mitophagy via Detection of Mitochondrial pH Variation
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200217
Abstract: Impaired mitophagy hinders the clearance of damaged mitochondria, inducing pathological states. Knowledge of this phenomenon is key to diagnosing certain diseases and understanding their pathogenesis. Mitophagy involves an acidization process that could serve as an… read more here.
Keywords: variation; mitophagy; detection; based fluorescent ... See more keywords
Ox-LDL aggravates contrast-induced injury of renal tubular epithelial cells.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23379
Abstract: Hypercholesterolemia can aggravate contrast-induced acute kidney injury, and the exacerbation of renal tubular epithelial cell (RTEC) injury is a major cause. However, the exact mechanisms remain obscure. Mitophagy, a type of autophagy, selectively eliminates damaged… read more here.
Keywords: induced injury; contrast induced; renal tubular; mitophagy ... See more keywords
Rab9‐dependent autophagy is required for the IGF‐IIR triggering mitophagy to eliminate damaged mitochondria
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26346
Abstract: Mitochondria dysfunction is the major characteristic of mitophagy, which is essential in mitochondrial quality control. However, excessive mitophagy contributes to cell death in a number of diseases, including ischemic stroke and hepatotoxicity. Insulin‐like growth factor… read more here.
Keywords: iir; autophagy required; dependent autophagy; igf iir ... See more keywords
Regulation of mitophagy through HIF‐1α/miR‐140‐5p/PARKIN axis in acute kidney injury
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23523
Abstract: Mitochondria homeostasis plays an important role in acute kidney injury (AKI). In this study, we aimed at identifying the mechanism of mitophagy regulation in AKI. Activation of mitophagy after ischemic kidney injury was visualized with… read more here.
Keywords: mitophagy; kidney injury; regulation; mir 140 ... See more keywords
Inhibition of the BNIP3/NIX‐dependent mitophagy aggravates copper‐induced mitochondrial dysfunction in duck renal tubular epithelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23704
Abstract: The accumulation of copper (Cu) in the organisms could lead to kidney damage by causing mitochondrial dysfunction. Given that mitochondria are one of the targets of Cu poisoning, this study aimed to investigate the role… read more here.
Keywords: induced mitochondrial; bnip3 nix; renal tubular; mitochondrial dysfunction ... See more keywords
Monitoring of Atg5-Independent Mitophagy.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/7651_2017_16
Abstract: Mitophagy is a mitochondrial quality control mechanism where damaged and surplus mitochondria are removed by autophagy. There are at least two different mammalian autophagy pathways: the Atg5-dependent conventional pathway and an Atg5-independent alternative pathway; the… read more here.
Keywords: independent mitophagy; biology; monitoring atg5; atg5 independent ... See more keywords
A Method for In Vivo Induction and Ultrastructural Detection of Mitophagy in Sertoli Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7698-0_9
Abstract: An emerging body of evidences based on in vitro studies indicate that mitophagy (selective autophagic clearance of damaged mitochondria) is a prosurvival mechanism, specifically under exposure to various stressors. Sertoli cells (SCs) play essential roles… read more here.
Keywords: detection; induction ultrastructural; sertoli cells; mitophagy scs ... See more keywords
Triggering Mitophagy with Photosensitizers.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8873-0_40
Abstract: One can utilize light illumination to stimulate mitochondrial reactive oxygen species production through the use of mitochondria-specific photosensitizers. By proper tuning of the light dosage, the methodology permits probing of a multitude of mitochondrial damage… read more here.
Keywords: methodology; mitophagy photosensitizers; biology; triggering mitophagy ... See more keywords
Investigating Mitophagy and Mitochondrial Morphology In Vivo Using mito-QC: A Comprehensive Guide.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8873-0_41
Abstract: Autophagy evolved as a mechanism to sustain cellular homeostasis during instances of nutrient deprivation. Mounting evidence has also clarified that under basal and stress conditions, selective autophagy pathways can target the destruction of specific organelles.… read more here.
Keywords: mitochondrial morphology; vivo; mitophagy mitochondrial; investigating mitophagy ... See more keywords