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   Articles with "mitophagy" as a keyword



Engineered Extracellular Vesicles with SHP2 High Expression Promote Mitophagy for Alzheimer's Disease Treatment

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recommendations! Published in 2022 at "Advanced Materials"

DOI: 10.1002/adma.202207107

Abstract: Mitochondrial dysfunction is a fundamental pathological feature of Alzheimer's disease (AD). However, toxicity and poor brain enrichment of existing mitophagy inducers limit their further applications. In this study, a platform for AD therapy is developed… read more here.

Keywords: extracellular vesicles; alzheimer disease; high expression; mitophagy ... See more keywords

MCU Upregulation Overactivates Mitophagy by Promoting VDAC1 Dimerization and Ubiquitination in the Hepatotoxicity of Cadmium

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recommendations! Published in 2023 at "Advanced Science"

DOI: 10.1002/advs.202203869

Abstract: Cadmium (Cd) is a high‐risk pathogenic toxin for hepatic diseases. Excessive mitophagy is a hallmark in Cd‐induced hepatotoxicity. However, the underlying mechanism remains obscure. Mitochondrial calcium uniporter (MCU) is a key regulator for mitochondrial and… read more here.

Keywords: mcu; cadmium; mitophagy; hepatotoxicity ... See more keywords

Pyrimidine‐Based Fluorescent Probe for Monitoring Mitophagy via Detection of Mitochondrial pH Variation

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recommendations! Published in 2022 at "ChemBioChem"

DOI: 10.1002/cbic.202200217

Abstract: Impaired mitophagy hinders the clearance of damaged mitochondria, inducing pathological states. Knowledge of this phenomenon is key to diagnosing certain diseases and understanding their pathogenesis. Mitophagy involves an acidization process that could serve as an… read more here.

Keywords: variation; mitophagy; detection; based fluorescent ... See more keywords

Ox-LDL aggravates contrast-induced injury of renal tubular epithelial cells.

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recommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"

DOI: 10.1002/jbt.23379

Abstract: Hypercholesterolemia can aggravate contrast-induced acute kidney injury, and the exacerbation of renal tubular epithelial cell (RTEC) injury is a major cause. However, the exact mechanisms remain obscure. Mitophagy, a type of autophagy, selectively eliminates damaged… read more here.

Keywords: induced injury; contrast induced; renal tubular; mitophagy ... See more keywords
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Carvedilol Confers Neuroprotective Activity Through Modulating Ferroptosis Key Players and PINK1/PARKIN Mediated Mitophagy in an Experimental Parkinson's Rat Model

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recommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"

DOI: 10.1002/jbt.70607

Abstract: Parkinson's disease (PD) is the fastest growing neurodegenerative disorder worldwide. Available treatments are only symptomatic, urging the demand for new therapies. Ferroptosis is increasingly reported as a critical player in neurodegeneration. Meanwhile, ferroptosis is activated… read more here.

Keywords: key players; ferroptosis; mitophagy; ferroptosis mitophagy ... See more keywords
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Rab9‐dependent autophagy is required for the IGF‐IIR triggering mitophagy to eliminate damaged mitochondria

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recommendations! Published in 2018 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.26346

Abstract: Mitochondria dysfunction is the major characteristic of mitophagy, which is essential in mitochondrial quality control. However, excessive mitophagy contributes to cell death in a number of diseases, including ischemic stroke and hepatotoxicity. Insulin‐like growth factor… read more here.

Keywords: iir; autophagy required; dependent autophagy; igf iir ... See more keywords

Optimally Aligned Nerve Scaffolds with Sustained Astaxanthin Release Improve the Inflammatory Microenvironment through Mitophagy Activation.

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recommendations! Published in 2025 at "Small"

DOI: 10.1002/smll.202502939

Abstract: Effective repair of peripheral nerve injury (PNI) depends on the scaffold orientation and immunomodulatory capabilities of functionalized scaffolds, both of which substantially influence nerve regeneration. In this study, composite nerve scaffolds incorporating astaxanthin (AXT) and… read more here.

Keywords: nerve; mitophagy; nerve scaffolds; axt pcl ... See more keywords

Regulation of mitophagy through HIF‐1α/miR‐140‐5p/PARKIN axis in acute kidney injury

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recommendations! Published in 2022 at "Environmental Toxicology"

DOI: 10.1002/tox.23523

Abstract: Mitochondria homeostasis plays an important role in acute kidney injury (AKI). In this study, we aimed at identifying the mechanism of mitophagy regulation in AKI. Activation of mitophagy after ischemic kidney injury was visualized with… read more here.

Keywords: mitophagy; kidney injury; regulation; mir 140 ... See more keywords

Inhibition of the BNIP3/NIX‐dependent mitophagy aggravates copper‐induced mitochondrial dysfunction in duck renal tubular epithelial cells

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recommendations! Published in 2022 at "Environmental Toxicology"

DOI: 10.1002/tox.23704

Abstract: The accumulation of copper (Cu) in the organisms could lead to kidney damage by causing mitochondrial dysfunction. Given that mitochondria are one of the targets of Cu poisoning, this study aimed to investigate the role… read more here.

Keywords: induced mitochondrial; bnip3 nix; renal tubular; mitochondrial dysfunction ... See more keywords
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Monitoring of Atg5-Independent Mitophagy.

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recommendations! Published in 2018 at "Methods in molecular biology"

DOI: 10.1007/7651_2017_16

Abstract: Mitophagy is a mitochondrial quality control mechanism where damaged and surplus mitochondria are removed by autophagy. There are at least two different mammalian autophagy pathways: the Atg5-dependent conventional pathway and an Atg5-independent alternative pathway; the… read more here.

Keywords: independent mitophagy; biology; monitoring atg5; atg5 independent ... See more keywords

A Method for In Vivo Induction and Ultrastructural Detection of Mitophagy in Sertoli Cells.

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recommendations! Published in 2018 at "Methods in molecular biology"

DOI: 10.1007/978-1-4939-7698-0_9

Abstract: An emerging body of evidences based on in vitro studies indicate that mitophagy (selective autophagic clearance of damaged mitochondria) is a prosurvival mechanism, specifically under exposure to various stressors. Sertoli cells (SCs) play essential roles… read more here.

Keywords: detection; induction ultrastructural; sertoli cells; mitophagy scs ... See more keywords