Melatonin protects against developmental PBDE-47 neurotoxicity by targeting the AMPK/mitophagy axis.
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DOI: 10.1111/jpi.12871
Abstract: The neurotoxicity of 2,2',4,4'-tetrabromodiphenyl ether (PBDE-47) is closely linked to mitochondrial abnormalities while mitophagy is vital for mitochondrial homeostasis. However, whether PBDE-47 disrupts mitophagy contributing to impaired neurodevelopment remain elusive. Here, this study showed that… read more here.
Keywords: mitophagy axis; pbde; ampk mitophagy; neurotoxicity ... See more keywords