Investigating Mitophagy and Mitochondrial Morphology In Vivo Using mito-QC: A Comprehensive Guide.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8873-0_41
Abstract: Autophagy evolved as a mechanism to sustain cellular homeostasis during instances of nutrient deprivation. Mounting evidence has also clarified that under basal and stress conditions, selective autophagy pathways can target the destruction of specific organelles.… read more here.
Keywords: mitochondrial morphology; vivo; mitophagy mitochondrial; investigating mitophagy ... See more keywords
Honokiol improves cognitive impairment in APP/PS1 mice through activating mitophagy and mitochondrial unfolded protein response.
Sign Up to like & getrecommendations! Published in 2021 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2021.109741
Abstract: Activated mitophagy and mitochondrial unfolded protein response (UPRmt) has been reported to protect against mitochondrial dysfunction, which is closely related to the onset of Alzheimer's disease (AD). Honokiol (HKL, C18H18O2) is a kind of natural… read more here.
Keywords: hkl; mitophagy mitochondrial; ps1 mice; mitochondrial unfolded ... See more keywords
Sesamin Alleviates Asthma Airway Inflammation by Regulating Mitophagy and Mitochondrial Apoptosis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c07877
Abstract: Bronchial asthma poses a considerable burden on both individual patients and public health. Sesamin is a natural lignan that relieves asthma. However, the potential regulatory mechanism has not been fully validated. In this study, we… read more here.
Keywords: apoptosis; asthma airway; mitophagy mitochondrial; sesamin ... See more keywords
Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13662
Abstract: Osteoarthritis (OA) is the most common age‐related joint disorder with no effective therapy. According to the World Health Organization, OA affects over 500 million people and is characterized by degradation of cartilage and other joint… read more here.
Keywords: health; mitochondrial health; mitophagy mitochondrial; cartilage degeneration ... See more keywords
Mitophagy, Mitochondrial Dynamics, and Homeostasis in Cardiovascular Aging
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/9825061
Abstract: Biological aging is an inevitable and independent risk factor for a wide array of chronic diseases including cardiovascular and metabolic diseases. Ample evidence has established a pivotal role for interrupted mitochondrial homeostasis in the onset… read more here.
Keywords: homeostasis; mitophagy mitochondrial; mitochondrial homeostasis; mitochondrial dynamics ... See more keywords
Qishen Granule Protects against Doxorubicin-Induced Cardiotoxicity by Coordinating MDM2-p53-Mediated Mitophagy and Mitochondrial Biogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/4344677
Abstract: Doxorubicin (DOX), the anthracycline chemotherapeutic agent, is widely used for the treatment of various cancers. However, its clinical application is compromised by dose-dependent and fatal cardiotoxicity. This study is aimed at investigating the cardioprotective effects… read more here.
Keywords: mitochondrial biogenesis; mitophagy mitochondrial; cardiotoxicity; p53 ... See more keywords
Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations
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DOI: 10.1212/wnl.0000000000003491
Abstract: Objective: To investigate mitophagy in 5 patients with severe dominantly inherited optic atrophy (DOA), caused by depletion of OPA1 (a protein that is essential for mitochondrial fusion), compared with healthy controls. Methods: Patients with severe… read more here.
Keywords: opa1 mutations; mitophagy mitochondrial; optic atrophy; dysregulated mitophagy ... See more keywords
Nutraceuticals/Drugs Promoting Mitophagy and Mitochondrial Biogenesis May Combat the Mitochondrial Dysfunction Driving Progression of Dry Age-Related Macular Degeneration
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14091985
Abstract: In patients with age-related macular degeneration (AMD), the crucial retinal pigment epithelial (RPE) cells are characterized by mitochondria that are structurally and functionally defective. Moreover, deficient expression of the mRNA-editing enzyme Dicer is noted specifically… read more here.
Keywords: related macular; age related; macular degeneration; mitophagy mitochondrial ... See more keywords