Mitoquinone mitigates paraquat‐induced A549 lung epithelial cell injury by promoting MFN1/MFN2‐mediated mitochondrial fusion
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23127
Abstract: Paraquat (PQ) poisoning often leads to severe lung injuries, in which the mitochondria damage plays a critical role. Mitoquinone (MitoQ), a newly designed mitochondria‐targeted antioxidant, has been proved for its benefit in mitochondria protection. However,… read more here.
Keywords: mitoq; cell; mfn1; lung ... See more keywords
MitoQ protects against liver injury induced by severe burn plus delayed resuscitation by suppressing the mtDNA-NLRP3 axis.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106189
Abstract: INTRODUCTION Liver injury induced by burn plus delayed resuscitation (B + DR) is life threatening in clinical settings. Mitochondrial damage and oxidative stress may account for the liver injury. MitoQ is a mitochondria-targeted antioxidant. We aimed to… read more here.
Keywords: mitoq; resuscitation; liver injury; mtdna nlrp3 ... See more keywords
Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2019.101100
Abstract: Increasing evidence indicates that mitochondrial-associated redox signaling contributes to the pathophysiology of heart failure (HF). The mitochondrial-targeted antioxidant, mitoquinone (MitoQ), is capable of modifying mitochondrial signaling and has shown beneficial effects on HF-dependent mitochondrial dysfunction.… read more here.
Keywords: mitoq; dysfunction; fibrosis; pressure overload ... See more keywords
Response to: The mitochondria-targeted antioxidant MitoQ attenuates exercise-induced mitochondrial DNA damage (Williamson et al., available online 6 August 2020, 101,673)
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101732
Abstract: Williamson and colleagues present important data on the effects of MitoQ - an antioxidant compound targeted to mitochondria - on mtDNA damage following exercise. Future studies are needed to elucidate, whether or not the observed… read more here.
Keywords: dna damage; mitoq; damage; response mitochondria ... See more keywords
MitoQ ameliorates testis injury from oxidative attack by repairing mitochondria and promoting the Keap1‐Nrf2 pathway
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2019.03.001
Abstract: ABSTRACT Mitochondrial dysfunctions induced by oxidative stress could play a pivotal role in the development of testicular damage and degeneration, leading to impaired fertility in adulthood. MitoQ as mitochondria‐targeted antioxidant has been used in many… read more here.
Keywords: testis; injury oxidative; mitoq; injury ... See more keywords
Effect of mitochondria-targeted antioxidant on the regulation of the mitochondrial function of sperm during cryopreservation.
Sign Up to like & getrecommendations! Published in 2022 at "Andrologia"
DOI: 10.1111/and.14431
Abstract: Sperm mitochondrion is one of the major susceptible organelles that get damaged during cryopreservation. The study aimed to minimize mitochondrial dysfunction and oxidative stress during sperm cryopreservation using mitochondria-specific antioxidants. For this, semen was collected… read more here.
Keywords: mitochondrial function; sperm cryopreservation; cryopreservation; mitochondria targeted ... See more keywords
Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Physiology"
DOI: 10.1152/japplphysiol.00670.2017
Abstract: Aortic stiffening is a major independent risk factor for cardiovascular diseases, cognitive dysfunction, and other chronic disorders of aging. Mitochondria-derived reactive oxygen species are a key source of arterial oxidative stress, which may contribute to… read more here.
Keywords: old mice; mitochondria targeted; age; mitoq ... See more keywords
Mitochondria-Targeted Antioxidant Mitoquinone Maintains Mitochondrial Homeostasis through the Sirt3-Dependent Pathway to Mitigate Oxidative Damage Caused by Renal Ischemia/Reperfusion
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/2213503
Abstract: Mitochondrial dysfunction is a critical factor contributing to oxidative stress and apoptosis in ischemia-reperfusion (I/R) diseases. Mitoquinone (MitoQ) is a mitochondria-targeted antioxidant whose potent anti-I/R injury capacity has been demonstrated in organs such as the… read more here.
Keywords: mitoq; sirt3; damage; oxidative damage ... See more keywords
Abstract 4779: MnSOD mimetic mitoquinone mesylate (MitoQ) increases DCLK1+pancreatic cancer stem cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4779
Abstract: Mitochondrially-generated reactive oxygen species (mROS) have been shown to induce acinar-to-ductal metaplasia (ADM). ADM, in presence of an oncogenic KRAS mutation, is an initiating step for progression to pancreatic intraepithelial neoplasia (PanIN) and eventually pancreatic… read more here.
Keywords: mitoq; cancer stem; mnsod mimetic; stem cells ... See more keywords
Abstract 288: Mitoq Regulates Redox-related Non-coding Rnas to Improve Mitochondrial Network in Pressure Overload Heart Failure
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.288
Abstract: Background: Previous studies show that mitochondrial network excitability, or the propagation of ROS signals, is impaired in cardiomyocytes from failing hearts. While oxidative stress has been implicated in heart failure (HF)-associated mitochondrial network abnormality, the… read more here.
Keywords: pressure overload; network; mitochondrial network; coding rnas ... See more keywords
The Mitochondria-Targeting Agent MitoQ Improves Muscle Atrophy, Weakness and Oxidative Metabolism in C26 Tumor-Bearing Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.861622
Abstract: Cancer cachexia is a debilitating syndrome characterized by skeletal muscle wasting, weakness and fatigue. Several pathogenetic mechanisms can contribute to these muscle derangements. Mitochondrial alterations, altered metabolism and increased oxidative stress are known to promote… read more here.
Keywords: mitoq; metabolism; muscle; mitochondria targeting ... See more keywords