Oral subchronic toxicity study and genetic toxicity evaluation of mitoquinone mesylate
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4654
Abstract: Mitochondrial dysfunction and excessive reactive oxygen species production contributes to the pathophysiology of aging. Coenzyme Q10 is thought to protect mitochondria from oxidative damage; thus, mitoquinone was developed as mitochondria‐targeted analogue with similar antioxidant activity.… read more here.
Keywords: mitoquinone; oral subchronic; mitoquinone mesylate; toxicity ... See more keywords
Low-Dose Acetylsalicylic Acid and Mitochondria-Targeted Antioxidant Mitoquinone Attenuate Non-Alcoholic Steatohepatitis in Mice
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12040971
Abstract: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. NAFLD can evolve from simple fatty liver to non-alcoholic steatohepatitis (NASH), and ultimately, to cirrhosis. Inflammation and oxidative stress, promoted by mitochondrial dysfunction,… read more here.
Keywords: non alcoholic; alcoholic steatohepatitis; expression; mice ... See more keywords