Identification of unique and shared mitochondrial DNA mutations in neurodegeneration and cancer by single-cell mitochondrial DNA structural variation sequencing (MitoSV-seq)
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DOI: 10.1016/j.ebiom.2020.102868
Abstract: Background Point mutations and structural variations (SVs) in mitochondrial DNA (mtDNA) contribute to many neurodegenerative diseases. Technical limitations and heteroplasmy, however, have impeded their identification, preventing these changes from being examined in neurons in healthy… read more here.
Keywords: mitochondrial dna; mitosv seq; cell; dna structural ... See more keywords