Simultaneous determination of mitotane, its metabolite and 5 steroid hormones in urine samples by capillary electrophoresis using β-CD2 SDS1 complexes as hydrophobic compounds solubilizers.
Sign Up to like & getrecommendations! Published in 2021 at "Electrophoresis"
DOI: 10.1002/elps.202100250
Abstract: Mitotane is a cytotoxic drug used in the treatment of inoperable adrenocortical carcinoma (ACC), it inhibits steroidogenesis as well, and therefore monitoring the level of steroid hormones in patients treated with mitotane is a crucial… read more here.
Keywords: simultaneous determination; mitotane; cd2 sds1; steroid hormones ... See more keywords
Frequency and outcome of SARS-CoV-2 infection in patients with adrenocortical carcinoma followed at a reference center in Italy
Sign Up to like & getrecommendations! Published in 2021 at "Endocrine"
DOI: 10.1007/s12020-020-02569-x
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) infection rapidly expanded and swiftly led to a public health crisis worldwide. Cancer patients infected by SARS-CoV-2 are at greater risk for severe illness and related death than… read more here.
Keywords: mitotane; infection; sars cov; cov infection ... See more keywords
Early progression under mitotane and polychemotherapy does not mean failure in adrenocortical carcinoma patient.
Sign Up to like & getrecommendations! Published in 2017 at "Annales d'endocrinologie"
DOI: 10.1016/j.ando.2016.10.001
Abstract: A 52-year-old female underwent surgery in March 2009 or a localized non-secretory adrenocortical carcinoma (ACC) f 17 cm. A Weiss score of 9 with a mitotic rate of more han 5/50HPF and a Ki67 of… read more here.
Keywords: adrenocortical carcinoma; mitotane; early progression; response ... See more keywords
Tumoral hypoglycemia: a case report.
Sign Up to like & getrecommendations! Published in 2017 at "Endocrinologia, diabetes y nutricion"
DOI: 10.1016/j.endinu.2017.05.005
Abstract: La hipoglucemia es un efecto adverso frecuente del tratamiento de la diabetes, pero muy raro en personas sin diabetes. La secreción de sustancias hipoglucemiantes por tumores de célula beta (insulinomas) o de otra estirpe1, es… read more here.
Keywords: mitotane; con; hypoglycemia case; tumoral hypoglycemia ... See more keywords
Circannual variation of mitotane and its metabolites plasma levels in patients with adrenocortical carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmacy and Pharmacology"
DOI: 10.1111/jphp.12798
Abstract: Mitotane is the reference drug for the adrenocortical carcinoma treatment; its pharmacological activity seems to depend on drug transformation in two active metabolites: o,p'‐DDE (dichlorodiphenylethene) and o,p'‐DDA (dichlorodiphenylacetate). Mitotane and metabolites are lipophilic agents; thus,… read more here.
Keywords: adrenocortical carcinoma; mitotane; variation; metabolites plasma ... See more keywords
Successful administration of mitotane (O, p′-DDD) in pediatric oncology
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology Pharmacy Practice"
DOI: 10.1177/10781552221076795
Abstract: Introduction Mitotane (o, p′-DDD) is a molecule that was developed many years ago for adrenal cortical carcinoma, but no suitable pediatric dosage form is available for administration to young children. Mitotane requires therapeutic drug monitoring… read more here.
Keywords: oncology; successful administration; mitotane ddd; mitotane ... See more keywords
Objective response and prolonged stable disease in refractory adrenocortical carcinoma treated with cabozantinib: An international case series and protocols of phase II clinical trials.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e16118
Abstract: e16118 Background: Median overall survival (OS) in advanced adrenocortical (ACC) is only 12-15 months. Previous clinical trials with oral multi-kinase inhibitors (MKI) were negative likely due to inadvertent drug interaction with mitotane. Objective: To investigate… read more here.
Keywords: response; objective response; mitotane; stable disease ... See more keywords
Spironolactone is associated with reduced mitotane levels in adrenocortical carcinoma patients.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine-related cancer"
DOI: 10.1530/erc-21-0202
Abstract: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a poor prognosis. Mitotane, a derivative of the pesticide DDT, has been used successfully as first line chemotherapy since the 1960s, if maintained within a narrow… read more here.
Keywords: spl; mitotane levels; spironolactone; mitotane ... See more keywords
Key factors for effective mitotane therapy in children with adrenocortical carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine-related cancer"
DOI: 10.1530/erc-22-0146
Abstract: Adjuvant treatment with mitotane and chemotherapy is recommended for paediatric advanced and metastatic adrenocortical carcinoma (ACC). Yet, questions on indication, dosage, and length of therapy are unanswered. Data from the German Paediatric Oncology Haematology-Malignant Endocrine… read more here.
Keywords: therapy; mitotane treatment; mitotane; adrenocortical carcinoma ... See more keywords
Identifying mitotane-induced mitochondria-associated membranes dysfunctions: metabolomic and lipidomic approaches
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DOI: 10.18632/oncotarget.18968
Abstract: Mitotane (o,p’DDD), the most effective drug in adrenocortical carcinoma, concentrates into the mitochondria and impacts mitochondrial functions. To address the molecular mechanisms of mitotane action and to identify its potential target, metabolomic and lipidomic approaches… read more here.
Keywords: lipidomic approaches; mitotane; mitochondria associated; mitotane induced ... See more keywords
Change of treatment modality and outcomes of adrenocortical carcinoma: a retrospective review of single tertiary center experience over 24 years
Sign Up to like & getrecommendations! Published in 2022 at "Gland Surgery"
DOI: 10.21037/gs-22-274
Abstract: Background Adrenocortical carcinoma, a rare malignancy, has a poor prognosis, and the treatment modalities have not been well established. This study aimed to analyze the trend of treatment modalities and outcomes of patients with adrenocortical… read more here.
Keywords: patients adrenocortical; patients stage; mitotane; adrenocortical carcinoma ... See more keywords