Simultaneous determination of mitotane, its metabolite and 5 steroid hormones in urine samples by capillary electrophoresis using β-CD2 SDS1 complexes as hydrophobic compounds solubilizers.
Sign Up to like & getrecommendations! Published in 2021 at "Electrophoresis"
DOI: 10.1002/elps.202100250
Abstract: Mitotane is a cytotoxic drug used in the treatment of inoperable adrenocortical carcinoma (ACC), it inhibits steroidogenesis as well, and therefore monitoring the level of steroid hormones in patients treated with mitotane is a crucial… read more here.
Keywords: simultaneous determination; mitotane; cd2 sds1; steroid hormones ... See more keywords
Frequency and outcome of SARS-CoV-2 infection in patients with adrenocortical carcinoma followed at a reference center in Italy
Sign Up to like & getrecommendations! Published in 2021 at "Endocrine"
DOI: 10.1007/s12020-020-02569-x
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) infection rapidly expanded and swiftly led to a public health crisis worldwide. Cancer patients infected by SARS-CoV-2 are at greater risk for severe illness and related death than… read more here.
Keywords: mitotane; infection; sars cov; cov infection ... See more keywords
Early progression under mitotane and polychemotherapy does not mean failure in adrenocortical carcinoma patient.
Sign Up to like & getrecommendations! Published in 2017 at "Annales d'endocrinologie"
DOI: 10.1016/j.ando.2016.10.001
Abstract: A 52-year-old female underwent surgery in March 2009 or a localized non-secretory adrenocortical carcinoma (ACC) f 17 cm. A Weiss score of 9 with a mitotic rate of more han 5/50HPF and a Ki67 of… read more here.
Keywords: adrenocortical carcinoma; mitotane; early progression; response ... See more keywords
Tumoral hypoglycemia: a case report.
Sign Up to like & getrecommendations! Published in 2017 at "Endocrinologia, diabetes y nutricion"
DOI: 10.1016/j.endinu.2017.05.005
Abstract: La hipoglucemia es un efecto adverso frecuente del tratamiento de la diabetes, pero muy raro en personas sin diabetes. La secreción de sustancias hipoglucemiantes por tumores de célula beta (insulinomas) o de otra estirpe1, es… read more here.
Keywords: mitotane; con; hypoglycemia case; tumoral hypoglycemia ... See more keywords
Recovery of adrenal function after stopping mitotane in patients with adrenocortical carcinoma.
Sign Up to like & getrecommendations! Published in 2024 at "European journal of endocrinology"
DOI: 10.1093/ejendo/lvae007
Abstract: OBJECTIVE Mitotane is the standard therapy of adrenocortical carcinoma (ACC) due to its relative selectivity of its cytotoxic effects towards adrenocortical cells. Therefore, it virtually always leads to adrenal insufficiency. Frequency and characteristics of hypothalamic-pituitary-adrenal… read more here.
Keywords: time; discontinuation; adrenal recovery; recovery ... See more keywords
P50 - Impact of lenvatinib, mitotane and radiotherapy on adrenocortical carcinoma cells: an in vitro analysis
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Endocrinology"
DOI: 10.1093/ejendo/lvaf168.092
Abstract: Adrenocortical carcinoma (ACC) is a rare, therapy-resistant malignancy with limited treatment options. Considering the role of radiotherapy in managing metastatic disease, as well as associated complications, it is desirable to investigate the impact of irradiation… read more here.
Keywords: cell lines; jil 2266; lenvatinib mitotane; mitotane ... See more keywords
External validation of the S-GRAS score for predicting recurrence in patients with adrenocortical carcinoma: implications for adjuvant mitotane therapy.
Sign Up to like & getrecommendations! Published in 2025 at "European journal of endocrinology"
DOI: 10.1093/ejendo/lvaf171
Abstract: BACKGROUND Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with variable outcomes post-adrenalectomy. The S-GRAS score integrates five clinical and pathological factors to predict prognosis but requires external validation in diverse settings. METHODS We validated… read more here.
Keywords: adjuvant mitotane; gras score; mitotane; adrenocortical carcinoma ... See more keywords
Circannual variation of mitotane and its metabolites plasma levels in patients with adrenocortical carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmacy and Pharmacology"
DOI: 10.1111/jphp.12798
Abstract: Mitotane is the reference drug for the adrenocortical carcinoma treatment; its pharmacological activity seems to depend on drug transformation in two active metabolites: o,p'‐DDE (dichlorodiphenylethene) and o,p'‐DDA (dichlorodiphenylacetate). Mitotane and metabolites are lipophilic agents; thus,… read more here.
Keywords: adrenocortical carcinoma; mitotane; variation; metabolites plasma ... See more keywords
Successful administration of mitotane (O, p′-DDD) in pediatric oncology
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology Pharmacy Practice"
DOI: 10.1177/10781552221076795
Abstract: Introduction Mitotane (o, p′-DDD) is a molecule that was developed many years ago for adrenal cortical carcinoma, but no suitable pediatric dosage form is available for administration to young children. Mitotane requires therapeutic drug monitoring… read more here.
Keywords: oncology; successful administration; mitotane ddd; mitotane ... See more keywords
Objective response and prolonged stable disease in refractory adrenocortical carcinoma treated with cabozantinib: An international case series and protocols of phase II clinical trials.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e16118
Abstract: e16118 Background: Median overall survival (OS) in advanced adrenocortical (ACC) is only 12-15 months. Previous clinical trials with oral multi-kinase inhibitors (MKI) were negative likely due to inadvertent drug interaction with mitotane. Objective: To investigate… read more here.
Keywords: response; objective response; mitotane; stable disease ... See more keywords
7888 Mitotane Induces Different Modes Of Cell Death In Treatment Resistant And Sensitive Models Of Adrenocortical Carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvae163.239
Abstract: Abstract Disclosure: S. Feely: None. N. Mullen: None. C. Hong: None. C. Hantel: None. W.E. Rainey: None. M.C. Dennedy: None. Adrenocortical carcinoma (ACC) is a rare aggressive cancer with poor survival. Adjuvant mitotane is the… read more here.
Keywords: none; mitotane; treatment; cell death ... See more keywords